Traumatic Brain Injury and Neurovascular Disturbances

Concussive Injury in Human Forebrain Organoids Alters Neurogenesis and Neuroimmune Signaling

This study uses human forebrain organoids to show that concussive injury affects neurogenesis and neuroimmune signaling differently depending on developmental stage.

Targeting the RNA regulator HuR in acute traumatic brain injury mitigates secondary injury and improves functional outcome by suppressing neuroinflammation

This study shows that inhibiting HuR with SRI-42127 reduces neuroinflammation and secondary injury after TBI, improving functional outcomes in mice.

Sex-Dependent Effects of Creatine Hydrochloride on Neuroinflammation, Neuronal Survival, and Inhibitory Synaptic Remodeling Following Traumatic Brain Injury in Mice.

This study investigates the neuroprotective effects of Creatine Hydrochloride (C-HCl) on traumatic brain injury (TBI) in mice, finding sex-dependent benefits in reducing neuroinflammation, neurodegeneration, and inhibitory synaptic remodeling.

Trigeminal Nerve Stimulation Attenuates Traumatic Brain Injury-Induced Neuronal Damage via CGRP-PINK1 Mitophagy Axis

This paper shows that trigeminal nerve stimulation reduces traumatic brain injury-induced neuronal damage by preserving mitochondrial function through the CGRP-PINK1 mitophagy pathway.

5-HT1A Antagonist WAY-100635 Prevents Chronic Neurodegeneration and Immune Activation After TBI

This study shows that WAY-100635, a 5-HT1A antagonist, reduces chronic neurodegeneration and immune activation after TBI by preserving neurons, synapses, and visual function.

Intranasal L-MYC Neural Stem Cells Restore Neurovascular and Neuroimmune Homeostasis After TBI via CX3CL1 Upregulation and ICAM-1 Downregulation

This study shows that intranasal LMNSC01 treatment reduces neuroimmune and neurovascular dysfunction after TBI by modulating ICAM-1 and CX3CL1 expression in both male and female rats.

The effect of an ultrasound-activated electrospun piezoelectric hydrogel scaffold on post-traumatic brain injury motor function in Drosophila melanogaster

This study tests a piezoelectric hydrogel scaffold with ultrasound activation for motor recovery after TBI in Drosophila, showing increased pass rates but limited statistical power.

Loss of C3 and CD14 reduces region-specific neuroinflammation in a murine polytrauma model

This study shows that loss of C3 and CD14 reduces neuroinflammation in a murine polytrauma model, with differential effects across brain regions.

Traumatic Brain Injury induces persistent behavioural deficits that are rescued by the antiepileptic drug Levetiracetam

This study investigates the long-term behavioral effects of traumatic brain injury (TBI) in larval zebrafish and evaluates the efficacy of levetiracetam (LEV) in mitigating these deficits.

Temporal transcriptomic remodeling after controlled cortical impact reveals delayed AQP4/SNTA1 expression imbalance associated with ion-homeostatic remodeling

The paper identifies a delayed AQP4/SNTA1 expression imbalance linked to ion-homeostatic remodeling in chronic traumatic brain injury using temporally-resolved transcriptomic and proteomic data.

Nrf2 regulates ICAM-1-mediated neutrophil extracellular trap formation after traumatic brain injury.

This study shows that Nrf2 regulates ICAM-1-mediated neutrophil extracellular trap formation after traumatic brain injury, protecting neurovascular integrity and improving functional recovery.

Comparative transcriptomic analysis reveals conserved injury responses and divergent molecular responses underlying early regenerative competence following traumatic brain injury

The paper compares transcriptomic responses to traumatic brain injury across species, finding conserved injury responses and zebrafish-specific repair mechanisms.

Conserved microglial programmes, non-transferable classifiers: boundaries of the single-cell TBI molecular clock

This paper evaluates the transferability of a single-cell molecular clock for traumatic brain injury (TBI) staging across datasets, finding poor cross-dataset generalization and identifying a conserved microglial gene-expression programme as the reproducible component.

Regenerative Neural Stem Cell Therapy Improves Multidomain Neurological Deficits after Traumatic Brain Injury in Nonhuman Primates

This study shows that a human neural stem cell therapy improves multiple neurological functions in nonhuman primates with traumatic brain injury.

AP-1 activation in Drosophila neuropil ensheathing glia improves traumatic brain injury survival

The paper investigates AP-1 activation in Drosophila glial subtypes after traumatic brain injury and finds that AP-1 activation in neuropil ensheathing glia improves survival.

Semaphorin 3A promotes resilience of sleep and cognition to brain injury

This study shows that Semaphorin-3A supports sleep and cognitive resilience after brain injury by maintaining sleep architecture and memory consolidation.

Hv1 proton channel is essential for splenic antibacterial defense and immune homeostasis during the chronic phase of traumatic brain injury in male mice

This study shows that Hv1 deficiency in mice leads to increased mortality and immune dysfunction after TBI, with significant effects on splenic antibacterial defense and immune homeostasis.

Tlr4 and Nlrp3 Inflammasome Signaling Drive a Delayed Secondary Wave of Hyperexcitability After TBI in Larval Zebrafish: Implications for Post-Traumatic Epileptogenesis

This study identifies a delayed secondary inflammatory wave driven by Tlr4 and Nlrp3 inflammasome signaling that contributes to post-traumatic epileptogenesis in larval zebrafish, suggesting a therapeutic window for anti-inflammatory interventions.

A 3D Human Neuron-on-Chip Platform to Monitor Neuronal Injury Responses

This study introduces a 3D Neuron-on-Chip platform to study neuronal injury responses in human prefrontal cortex neurons, revealing biphasic injury responses and stage-specific inflammatory signaling.

Distinct spatiotemporal immunometabolic remodeling following acute traumatic brain injury

This study characterizes the spatiotemporal metabolic changes in the brain after traumatic injury, identifying distinct metabolic responses in microglia/macrophages and astrocytes.

Rubicon modulates neuroimmune responses following traumatic brain injury

This study shows that Rubicon promotes neuroinflammation and oxidative stress after traumatic brain injury by affecting autophagy and ROS production, and suggests it as a potential therapeutic target.

Histological assessment of integrated human cortical organoid grafts after controlled cortical impact

This study develops an in vivo model of human traumatic brain injury using human cortical organoids transplanted into rats, showing injury progression and neuroinflammatory responses.

Whole-Brain, Region-Specific Astrocyte Reactivity and Morphological Remodeling After Diffuse Traumatic Brain Injury in A Gyrencephalic Ferret Model

This study quantifies astrocyte reactivity and morphological changes in a ferret TBI model using AI and atlas-based mapping, revealing region-specific responses and structural remodeling.

Pediatric traumatic brain injury elicits acute neuroinflammation and long-term changes in social, cognitive, and decision-making behaviors in male and female rats

This study shows that pediatric TBI in rats leads to long-term cognitive, social, and decision-making impairments, linked to acute neuroimmune changes.

Tau Isoform Expression Drives Disease Outcomes Following a Single Closed Head Injury

This study shows that expressing 3R tau isoforms in mice alters the disease course of traumatic brain injury, leading to different white matter damage and behavioral outcomes at subacute and chronic stages.

Early retinal microglial activation and ganglion cell dysfunction following severe traumatic brain injury in mice

This study examines retinal microglial activation and ganglion cell dysfunction in mice after severe traumatic brain injury, showing early inflammatory and apoptotic changes detectable within 48 hours.

Rapid Intracellular Delivery of Human Heat Shock Protein 72 Prevents Memory Loss and Inhibits Neurodegeneration up to 9 Days After a Blast Injury

This study evaluates Fv-HSP72 variants for reducing neurodegeneration and preserving memory after blast injury in rats, showing significant biomarker improvements and memory retention.

Chronic Stress Exacerbates Long-term Microvascular Network Dysfunction Following Brain Trauma

This study shows that chronic stress worsens microvascular network dysfunction after brain trauma, reducing capillary coordination and vascular reactivity.

Neuronal Toll-like Receptor-4 regulation of Matrix Metalloproteinase-9 Activity Mediates Dentate Circuit Dysfunction after Traumatic Brain Injury

This study identifies a TLR4-MMP-9 signaling axis that drives early post-TBI dentate gyrus circuit dysfunction and behavioral deficits in rodents.

Protein Predictors of Worsening Cerebral Edema in Traumatic Brain Injury in Critically Ill Patients

The paper identifies a plasma protein biomarker panel and predictive model for early cerebral edema worsening in TBI patients and reveals a neuronal-synaptic injury network associated with edema progression.