Forensic and Genetic Research

HaploNet uses neural networks to infer population structure from whole-genome sequencing data, outperforming standard methods in distinguishing closely related populations.

The paper characterizes human genomic variations and mutation burden in Botswana using whole genome sequencing, identifying damaging variants and admixture patterns.

The paper evaluates prediction accuracy for eye, hair, and skin pigmentation in admixed Latin Americans using genomic and phenotypic data, finding that Random Forest and regression perform best, and that pigmentation SNPs improve accuracy, especially for skin color.

PyLAE predicts local ancestry from whole-genome sequencing or high-density genotyping data, efficiently handling large numbers of ancestral populations.

Genome-wide SNPs from 211 Southern Chinese, analysed with over 1,200 ancient and modern genomes, split the Yangtze River Farmer lineage into four language-linked sub-ancestries and date later migrations.

This study uses a graph embedding method to reconstruct the migration history of East Asian populations using SNP data from the 1000 Genomes Project and identifies SNPs associated with neurological diseases.

The paper shows Ancient Beringians have admixture from Amur River Basin populations and are not the deepest American lineage.

The paper characterizes the genetic structure of South Asian populations, identifies founder effects and high homozygosity, and develops a custom SNP array for genetic studies in the region.

This study shows that low coverage sequencing can effectively match relatives with genotyping arrays, achieving similar accuracy for close relatives and strong correlation for distant ones.

This study presents the first genomic analysis of early Islamic burials in the Levant, finding genomic similarity to modern Bedouins and Saudis rather than neighboring Levantine groups.

The paper introduces TPS, a genomic dating method for ancient genomes, which accurately dates Eurasian samples and resolves conflicts in paleogenomic data.

The paper constructs a haplotype network of 111,000 Han Chinese genomes to reveal fine-scale population structure and demographic history, identifying subclusters linked to geography, immigration, and cultural-linguistic factors.

This study analyzes genomic data to show Armenians remained unadmixed until the Bronze Age, then experienced a Sardinian-like genetic input, suggesting large-scale population movements in the Middle East.

The paper uses a Bayesian method to infer ancient demographic events and finds evidence of migration from Eurasian ancestors into Africa 40-70 thousand years ago.

This paper detects runs of homozygosity in ancient DNA to infer parental relatedness, finding low rates of close unions and a decline linked to agriculture adoption.

The paper analyzes ancient genomes from the Mokrin necropolis to study kinship, population structure, and status inheritance in an Early Bronze Age community.

The paper compares DNA extraction and sequencing methods for formalin-preserved ancient cadaver samples, finding FFPE and high-throughput sequencing to be more effective.

The paper introduces a method to detect short IBD segments using rare variant sharing, improving the identification of distant relatedness and older population divergence.

Haplotracker is a web tool that accurately identifies mitochondrial haplogroups using short DNA fragments, outperforming existing tools in prediction accuracy.

The paper develops a new method to assess shared weak selection signals across human populations using 1000 Genomes Phase 3 data, finding that weak selection increases population differences around coding regions.

XGMix is a gradient boosted tree method for local ancestry inference that is accurate, simple to use, and fast to train on consumer-level hardware.

This paper uses ancient and present-day genomic data to reconstruct the population history of East Asia, identifying key migrations and language dispersals.

Genome-wide and isotopic data from prehistoric Sicilians reveal a pre-farming connection to (south-) eastern Europe, and tentative initial evidence that hunter-gatherers adopted some Neolithic aspects prior to near-total replacement by early farmers.

The paper analyzes mtDNA from individuals with biparental transmission and finds no evidence of intermolecular recombination, supporting strict maternal inheritance.

This paper critiques Mikheyev et al.'s 2019 study on Khazar genomes, highlighting methodological flaws, irreproducibility, and unsupported claims.

This study tests hormone-specific antibody probes to label and isolate contributor cell populations in trace DNA mixtures, showing potential for improving DNA profiling success rates.

The paper uses Y-chromosome phylogenetic and phylogeographic analyses to show that non-African male lineages originated in East/South-east Asia 50,000-55,000 years ago, replacing earlier lineages.

The paper uses genetic genealogy to identify African American relatives of Ghanaian participants, supporting the reuniting of families separated by the Transatlantic Slave Trade.

This study analyzes the genetic structure of modern France using SNP data, revealing distinct genetic clusters and historical influences.