Wound Healing and Treatments

Single-nucleus chromatin accessibility time course of excisional wound repair in rat skin

The paper presents a time-course single-nucleus ATAC-seq dataset from rat skin wounds, revealing chromatin accessibility changes across repair phases.

Implications for Faster Healing with Fewer Applications: Sustained Graft Persistence and Favorable Wound-Healing Biology of a Proprietary Processed Placental Tissue Allograft

This study shows that XWRAP, a proprietary processed placental tissue allograft, maintains greater graft integrity and reduces the need for reapplication compared to conventional and commercial comparators.

An agent-based model of wound healing in fibroblast scratch assays

The paper develops an agent-based model of fibroblast scratch assays to simulate wound healing, achieving high accuracy in predicting cell behavior across different geometries.

The Structural Genome Shapes the Chronic Wound Microbiome

The paper investigates the association between genomic copy number variants and chronic wound microbiome species, finding significant links and highlighting the role of structural genomic variation in shaping the microbiome.

Persistent CCL3 expression sustains neutrophil recruitment and contributes to delayed wound healing in advanced age

This study shows that persistent CCL3 expression in aged wounds sustains neutrophil recruitment and delays healing by impairing inflammatory resolution.

A regenerative fibroblast competence field supports multiple cell fates in adult skin regeneration

This study identifies NCAM1 as a regulator of regenerative competence in adult skin wounds through single-cell RNA sequencing and functional analysis.

Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux

This paper introduces a wearable sensor that monitors gaseous flux from wounds to detect infections and track healing, showing VOC flux correlates with bacterial growth and provides early infection detection.

Abnormally low expression of tumor necrosis factor stimulated gene 6 (TSG-6) in obese type 2 diabetic mice contributes to altered inflammation and delayed cutaneous wound healing

This study shows that reduced TSG-6 expression in diabetic mice leads to inflammation and delayed wound healing, which can be reversed by reintroducing TSG-6.

Aged-associated changes in active YAP staining during impaired skin wound healing in aged mice and delayed wound closure in ICE mice

This study examines age-related changes in YAP signaling during skin wound healing in mice, finding altered temporal regulation and selective Ankrd1 elevation in aged wounds.

De Novo Regeneration of Rete Ridges during Cetacean skin wound healing

This study shows that tight-skinned Frasers Dolphins regenerate complex rete ridges with minimal scarring after large full-thickness wounds, despite high-tension and shear stress environments.

Proprietary Processing of Placental Tissue Allografts Influences Wound Healing Trajectories in a Rodent Excisional Skin Wound Model

This study compares proprietary and conventional processing of placental tissue allografts in a rodent wound model, finding the proprietary method promotes better wound resolution and reduced tissue injury.

Dual Traditional Chinese Medicine-Preconditioned Stem Cell Secretomes in Coaxial Electrospun Nanofibers Synergistically Accelerate Diabetic Wound Regeneration

This paper develops a coaxial nanofiber scaffold delivering TCM-preconditioned stem cell secretomes to accelerate diabetic wound healing.

Scaffold-mediated delivery of a miRNA-29b mimic mitigates excessive extracellular matrix deposition and matrix contraction in wound healing applications

This paper develops a collagen-GAG scaffold delivering miRNA-29b to reduce fibrosis by inhibiting myofibroblast activation and ECM accumulation in wound healing.

A role for CREB5 in skin wound healing

This study investigates CREB5's role in skin wound healing by comparing its effects in oral and skin keratinocytes, showing improved migration with CREB5 overexpression.

Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish

Loss of the rhomboid protease Rhbdl2 in zebrafish larvae speeds tail fin regrowth after injury, raises macrophage accumulation and Rac2 protein, and Rac2 knockdown reverses both effects.

Bioactive Spermidine-Crosslinked DNA Hydrogel for rapid homeostasis and accelerated wound healing

This paper develops a DNA hydrogel that rapidly stops bleeding and promotes tissue regeneration in mice by combining hemostasis with bioactive properties.

Colorimetric Hydrogel Dressing with Smartphone Detector for Point-of-Care Wound pH Monitoring

This paper develops a colorimetric hydrogel dressing that uses a smartphone camera to monitor wound pH in real-time, enabling point-of-care diagnostics for chronic wounds.

Tissue osmotic surveillance shapes susceptibility of zebrafish to wound infections

This study shows that isotonic solutions increase zebrafish wound susceptibility to Pseudomonas aeruginosa by affecting wound sealing and neutrophil recruitment.

Dual lineages of Langerhans cells cooperate to restore the immune barrier after skin injury

The paper identifies two distinct Langerhans cell lineages involved in restoring immune barrier function after skin injury.

Glycocalyx-Directed Enzymatic Hydrogels Unlocks Fibroblast Regeneration to Promote Diabetic Wound Healing

This paper develops glycocalyx-targeting hydrogels that enhance fibroblast regeneration in diabetic wounds by reversing pathological glycocalyx thickening and improving wound closure.

Self-powered electronics-free Wearable Disposable Electrotherapy (WDE) platform for accelerated wound healing

The paper introduces a disposable wearable electrotherapy patch that accelerates wound healing in rats by delivering electrical stimulation comparable to a conventional device, with reduced closure time and enhanced tissue remodeling.

Engineered Amphiregulin Promotes Tissue Healing via Dual Regenerative and Immunomodulatory Functions in Tissue-Resident Non-Immune Cells

This study shows engineered AREG promotes tissue healing by enhancing regeneration and suppressing inflammation in non-immune cells across murine models.

Fibroblast response to burn injury in larval zebrafish mirrors developmental maturation and is inhibited by infiltrating neutrophils

Vimentin-driven maturation of col1a1a-positive fibroblasts after larval zebrafish burn parallels fin development, but prolonged neutrophil presence delays fibroblast maturation and organized collagen regrowth.

Single-cell RNA-seq reveals conserved and divergent cellular states across wound types and species

This study integrates single-cell data from multiple wound types and species to identify shared and distinct cellular states and develops a predictive gene signature for chronic wound healing.

Behavioral and Functional Profiling of Acomys cahirinus Fibroblasts Reveals Enhanced Matrix Remodeling Capacity

This study profiles Acomys cahirinus fibroblasts to show that Col3A1 expression and senescence-associated cell states influence matrix remodeling, contributing to scarless regeneration.

Residual Hair Biomaterial Particulates Improve Dermal Regeneration and Combined with Electrical Stimulation Accelerates Skin Wound Closure

This study evaluates the effects of residual hair biomaterial particulates, electrical stimulation, and their combination on skin wound healing, finding they accelerate closure and improve tissue regeneration.

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways

This study uses transcriptomic profiling to identify metabolic, inflammatory, and oxidative stress pathways in diabetic porcine wound healing, supporting the model for therapeutic testing.

Exploring mechanisms of scar-free skin wound healing in adult zebrafish in comparison to mouse

The paper compares scar-free skin wound healing in zebrafish and mice, identifying differences in fibroblast behavior and collagen crosslinking mechanisms.

Controlled microtrauma opens a regenerative window for appendage-bearing skin repair

The paper uses controlled microtrauma combined with molecular cues to promote regenerative skin repair with appendages in animal models.

A Pro-Regenerative Petroleum Jelly-Based, Copper-Doped Bioactive Glass Ointment for Impaired Wound Healing in Metabolic Syndrome

This paper evaluates a copper-doped bioactive glass ointment for wound healing in metabolic syndrome, showing improved closure, regeneration, and reduced scarring.