Yan Wang

Digital molecular kinetics enabled by large-scale nanopore arrays for multidimensional biophysical profiling

This paper introduces a digital molecular kinetics platform using large-scale nanopore arrays to overcome limitations of traditional methods like SPR, enabling comprehensive thermodynamic-kinetic profiling and improved detection of molecular interactions.

Myristoylation licenses disordered viral VP4 protein to anchor to and perforate the membrane through phase separation

This study shows that myristoylation of VP4 enables membrane anchoring, phase separation, and pore formation in enteroviruses through multiple functional roles.

Abnormally low expression of tumor necrosis factor stimulated gene 6 (TSG-6) in obese type 2 diabetic mice contributes to altered inflammation and delayed cutaneous wound healing

This study shows that reduced TSG-6 expression in diabetic mice leads to inflammation and delayed wound healing, which can be reversed by reintroducing TSG-6.

SpacerScope: Binary-vectorized, genome-wide off-target profiling for RNA-guided nucleases without prior candidate-site bias

SpacerScope provides a high-speed, high-sensitivity off-target profiling tool for RNA-guided nucleases, accurately recovering all validated off-target sites and detecting complex indel-containing sites.

Discovery of a taxusin-mediated route to baccatin III enables its complete biosynthesis in engineered microbes

The paper identifies a novel biosynthetic pathway for baccatin III production using engineered microbes, achieving its complete de novo synthesis through enzymatic validation and pathway engineering.

Coculture of Collinsella aerofaciens and Bacteroides thetaiotaomicron under bile acid stress reveals vitamin B6 exchange

The paper examines how two gut microbes interact under bile acid stress, finding that one species helps the other survive by exchanging vitamin B6.

Functional and Structural Basis of Omicron BA.3.2.1 Spike

The paper analyzes the functional and structural characteristics of the SARS-CoV-2 BA.3.2.1 spike, showing trade-offs between immune evasion and replication fitness.

AutoPELSA: an automated sample preparation system for proteome-wide identification of target proteins of diverse ligands

AutoPELSA automates the PELSA workflow for proteome-wide ligand-protein interaction detection, enabling high-throughput analysis of both strong and low-affinity ligands.

Complete elucidation and heterologous reconstruction of the biosynthetic pathway of camptothecin

This study identifies the complete biosynthetic pathway of camptothecin, discovers missing enzymes, and validates the pathway through heterologous reconstruction in yeast.

A human-in-the-loop explanation framework for morphologically transparent AI predictions from whole-slide images

This paper introduces MorphoXAI, a human-in-the-loop framework for explaining AI predictions on whole-slide images, showing it provides accurate and interpretable histomorphological explanations at both global and local levels.

Natural killer cell dysfunction drives keloid pathogenesis

This study identifies NK cell dysfunction in keloids, showing IFN-γ suppresses fibroblast proliferation while AREG counteracts this, and systemic IFN-β drives NK cell exhaustion.

Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNS

This study identifies SerpinOLs as injury-responsive oligodendrocytes that modulate neuroinflammation and glial activation in both diseased and healthy CNS conditions.

MetaFold-RNA: Accurate prediction of RNA secondary structure using a meta-learning-guided deep network

MetaFold-RNA improves RNA secondary structure prediction using a meta-learning framework, achieving state-of-the-art results on unseen RNA families.

A resource for the comparison and integration of heterogeneous microbiome networks

The paper introduces MIND, a platform for comparing and integrating microbial interaction networks from diverse datasets.

Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy

The paper presents a proteogenomic approach to identify resistance-specific alterations in melanoma PDX models treated with MAPK inhibitors using custom curated databases.

PBN-PVT projection modulates negative affective states in mice

This study shows that the PBN-PVT projection modulates negative affective states in mice by inducing anxiety-like, aversion-like, and fear-like behaviors.

Geraniol Enhances Inhibitory Inputs to Paraventricular Thalamic Nucleus and Induces Sedation in Mice

This study shows that geraniol enhances inhibitory inputs to the paraventricular thalamic nucleus and induces sedation in mice by modulating neuronal activity and GABAA receptor function.

riboCIRC: a comprehensive database of translatable circRNAs

riboCIRC provides a database of translatable circRNAs with computational predictions, experimental validations, and cross-species conservation analysis.

Dual midbrain and forebrain origins of thalamic inhibitory interneurons

The paper identifies two developmental origins of thalamic inhibitory interneurons in mice and shows their distribution in the marmoset thalamus.