Wound Healing and Treatments

This study shows hypoxia accelerates wound healing by altering cell-cell and cell-matrix adhesion dynamics through DSG2 downregulation and ITGB3 biphasic regulation.

This study examines dermal endothelial cells from people with type 2 diabetes, finding they have altered migratory, angiogenic, and gene expression profiles compared to healthy cells.

This paper develops a layer-by-layer plasmonic implant for combination therapy against multidrug-resistant chronic wound biofilms, showing effective bacterial elimination and controlled drug release.

This study characterizes the genotypic and functional differences between healthy and pressure sore-derived fibroblasts, revealing reduced ECM protein expression and impaired myofibroblast differentiation.

UT-018, a stem cell chemoattractant, accelerates wound repair and hair follicle regeneration in mice by enhancing tissue repair processes and inducing anagen-phase transition.

This paper develops a composite biomaterial combining polyelectrolyte complex micelles with hyaluronic acid gels to deliver miR-92a inhibitors, enhancing angiogenesis and accelerating wound healing in diabetic mice.

This study differentiates HL-60 cells into immature neutrophil-like cells using DMSO and D3, showing their regenerative potential in corneal wound healing.

This study identifies a regeneration-specific macrophage population in mouse digit tip regeneration that uses BMP signaling and a unique metabolic profile to drive bone formation, absent in scar-forming injuries.

This study uses a diabetic mouse model to show that Enterococcus faecium persists in wounds due to impaired clearance and altered immune responses compared to non-diabetic mice.

This study evaluates a hydrogel-based delivery system for APOSEC™ in wound healing, finding improved release but non-uniform mixing and no significant efficacy difference compared to a benchmark gel.

This study shows that aging reduces and alters the senescence response in wound healing, leading to delayed repair due to fewer and less functional senescent cells.

This study identifies transcriptional regulators driving macrophage state transitions in diabetic wound healing using scRNA-seq and computational methods.

This paper develops a hydrogel patch that releases oxygen and buffers acidity in oral wound models, improving cell viability and pH balance.

This study shows that Schwann cell dysfunction contributes to diabetic wound healing impairment and that oncostatin M treatment partially improves wound repair in diabetic mice.

This study shows that exercise-induced sweat promotes wound healing in diabetic foot ulcers by enhancing re-epithelialization, collagen deposition, and angiogenesis in a mouse model.

This paper proposes a deep learning-based control framework for wound healing that accelerates closure by 17.71% in simulations and 40% in vivo.

This paper introduces a bioelectronic dressing that senses and treats chronic wounds through real-time biochemical monitoring, drug release, and electrical stimulation.

This study compares the effects of ultra-wideband low-intensity mechanical waves (UMUS) and low-intensity pulsed ultrasound (LIPUS) on wound healing in a rat amputation model, finding UMUS more effective in reducing wound size and promoting tissue repair.

The paper evaluates the in vivo efficacy of VeritaCell-derived autologous skin cell suspensions in a rat wound model, showing accelerated healing and reduced scarring.

This study shows basophils promote inflammation resolution and wound healing in both adult and aged mice by driving tissue remodeling and immunoregulatory functions.

This study shows that Smad7-based biologic treatment accelerates diabetic wound healing in mice and pigs by targeting keratinocytes and neutrophils, reducing inflammation and promoting tissue repair.

This study shows that different modes of macrophage cell death affect wound healing outcomes, with necroptosis impairing repair and apoptosis promoting better tissue recovery.

This study identifies osteopontin (OPN) as a critical mediator of tissue repair during Staphylococcus aureus skin infections by analyzing single-cell transcriptomics in a murine model.

The paper develops an engineered living material that uses NIR light to release a pro-angiogenic peptide, promoting capillary network formation in endothelial cultures.

This study uses proteomics to show that snail slime induces redox modulation, controlled apoptosis, and enhanced migration in human dermal fibroblasts, supporting its regenerative potential.

This study shows that increasing SPARC expression in mesenchymal stem cells enhances their secretome's ability to promote skin regeneration and wound healing.

This study uses a multidisciplinary approach to identify age-dependent expression patterns in porcine experimental wounds to improve objective wound age estimation in forensic cases.

This study evaluates bioabsorbable magnesium wires in a murine wound model, showing improved granulation tissue, reduced inflammation, and enhanced neovascularization.