Neuropeptides and Animal Physiology

This paper investigates how the dynorphin/kappa-opioid receptor system modulates excitation-inhibition balance in prefrontal cortical circuits through pathway-specific mechanisms.

This study shows that endogenous opioid Met-Enkephalin modulates thalamo-cortical excitation-inhibition balance by preferentially inhibiting GABAergic transmission in the ACC.

This study identifies a thyrostimulin-like neuroendocrine pathway in C. elegans that regulates growth and intestinal function through GPA2/GPB5 signaling.

The paper characterizes NMU-expressing neurons in the adult mouse brain using a Nmu-Cre knock-in model, revealing a midline modulatory circuit centered on the VMH.

This study investigates how insula dynorphin and kappa opioid receptor systems influence alcohol drinking in mice, revealing sex-specific effects on consumption and behavior.

This study shows PACAP modulates anxiety circuits by altering synaptic efficacy in BLA-ovBNST-adBNST pathways, leading to inhibition of adBNST and increased anxiety.

The paper shows opioid withdrawal reduces peptide activity in the amygdala by increasing neprilysin via PKA, disrupting synaptic transmission and potentially leading to compulsive drug use.

This study examines the morphology and neurochemical properties of the otic ganglion in chinchillas, revealing interspecies differences in structure and immunohistochemical characteristics.

The paper maps opioid receptor expression across brainstem circuits and identifies functional implications in respiratory and sensory pathways.

The paper examines changes in substance P, NPY, and their receptors in major depression by analyzing transcript levels in brain regions of suicide victims and controls.

This study shows that repetitive blast trauma in mice increases dynorphin and cytokines, which are reduced by a KOR antagonist, improving behavioral outcomes.

The paper uses single-cell RNA sequencing to identify and characterize neuropeptide and peptide hormone genes in pulmonary neuroendocrine cells from mice and humans, revealing their diverse signaling roles and potential endocrine functions.

This study identifies CART and acetylcholine as modulators of motor neuron output at C bouton synapses, affecting movement vigour through distinct but parallel mechanisms.

The paper reports a genome-wide map of neuropeptide-GPCR interactions in C. elegans, identifying 461 cognate peptide-GPCR pairs and uncovering their evolutionary conservation.

This study maps the distribution of corticotropin-releasing hormone (CRH) and CRH-binding protein (CRHBP) systems in the sea lamprey brain across developmental stages.

The paper analyzes opioid receptor blockade using PET data and models to determine optimal doses and timing for naloxone and naltrexone in humans.

The paper develops a MOR-specific Cre mouse line to study opioid receptor cell types and their molecular characteristics during opioid withdrawal.

This study characterizes neuropeptide Y interneurons in the nucleus accumbens and shows they are sensitive to mu opioid receptor activation, with sex- and receptor-dependent effects on synaptic transmission.

The paper generates and validates a CRF1:Cre transgenic rat to study the role of CRF1-expressing neurons in anxiety and nociception, finding that activation of these cells increases anxiety-like behavior and pain responses.

This study functionally characterizes a neuropeptide receptor in Aplysia neurons by expressing it exogenously and demonstrating its role in modulating neuronal excitability.

This study shows hypoxia increases NPY1R and NPY5R expression via HIFs in breast cancer cells, making them more responsive to NPY stimulation and enhancing proliferation and migration.

The paper was retracted due to errors in methods and data reporting, making the results and conclusions unreliable.

The paper identifies constitutive and acute transcriptomic effects of PACAP deficiency in mice, revealing distinct mechanisms of neuropeptide action on physiological and behavioral responses.

This study shows that dynorphin release in the prefrontal cortex during opioid withdrawal disrupts cognition, and KOR antagonism can block these effects.

This study shows that ACE inhibition enhances endogenous opioid signaling and reduces fentanyl-induced conditioned place preference in mice.

This study examines the role of GPR83 in anxiety-like behaviors through global and regional knockdown in male and female mice, revealing sex-dependent and brain region-specific effects.

The paper identifies KOR/Dyn signaling in the midbrain as promoting threat generalization, showing an inverted U relationship between threat intensity and discrimination.

This study identifies the Edinger-Westphal nucleus in mice as an obligately peptidergic population that modulates fear responses and analgesia.

The paper characterizes two MOR PAMs that enhance opioid antinociception without increasing adverse effects in mouse models.

This study investigates the distinct roles of norepinephrine and galanin in stress-induced anxiety-like behavior using genetic and pharmacological approaches in mice.