Topic · Public Health, Environmental and Occupational Health · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
97 papers
Amrita Chakrabarti, Monika Kaushik, Juveria Khan…·Shailja Singh
The paper reports a novel tRNA-derived peptide, tREP-18, with potent anti-leishmanial activity against L. donovani and PKDL isolates.
Bapi Biswas, Bhakti Laha, Pratyay Sengupta…·Monidipa Ghosh
This study characterizes a novel Leishmania donovani protein, ALSP, identifies it as a lipase, and suggests its role in virulence and potential as a vaccine target and biomarker.
Gabriel H. Negreira, Pieter Monsieurs, Hideo Imamura…·Malgorzata A. Domagalska
This paper uses high-throughput single-cell genome sequencing to analyze karyotype variation in a clonal Leishmania donovani population, revealing mosaic aneuploidy and its potential adaptive role.
Léa Cristina Castellucci, Lucas dos Santos de Almeida, Svetlana Cherlin…·Jenefer Mary Blackwell
This study conducts a genome-wide association study to identify genetic risk factors for cutaneous leishmaniasis in Brazil, finding novel associations and highlighting the regulatory role of IFNG-AS1 in interferon-gamma responses.
The paper upgrades POPSICLE for aneuploid genomes to study Leishmania population structure, revealing dichotomous zygosities and the role of sex in genetic diversity.