Neurological disorders and treatments

Coupled beta and high-frequency oscillations emerge from synchronized bursting in a minimal model of the parkinsonian subthalamic nucleus

This paper develops a computational model of the parkinsonian subthalamic nucleus showing how synchronized bursting produces beta-HFO coupling and explains HFO frequency shifts.

Differential value processing in the rostral and causal subthalamic nucleus during flexible and habitual decision-making in primates: Implications for cognitive dysfunction in Parkinson's disease

This study identifies a rostral-caudal functional organization in the subthalamic nucleus (STN) that supports flexible value updating and habitual behavior, revealing distinct roles for STN subregions in decision-making.

Acute scalp EEG signatures of anterior thalamic DBS in epilepsy:reproducible gamma power enhancement within an aperiodic spectral-state shift

The paper identifies consistent acute scalp EEG signatures of anterior thalamic DBS in epilepsy, showing gamma power enhancement and aperiodic parameter changes across multiple sessions.

Perisynaptic matrix gene variants underlie DystoniaGeneNet endophenotypes in isolated focal dystonia

This paper uses a deep learning model to identify genetic variants associated with isolated focal dystonia by leveraging neuroimaging endophenotypes.

FLEX-DBS: a flexible wireless platform for bilateral constant-current deep brain stimulation in freely moving rodents

FLEX-DBS is a wireless stimulator for bilateral DBS in rodents, offering programmable stimulation parameters and autonomous operation, with results showing increased immobility during high-amplitude stimulation.

Hindmarsh-Rose neuronal network with spike-timing-dependent plasticity demonstrates coordinated reset neuromodulation for Parkinson's disease

This paper uses a computational model to study how coordinated reset stimulation can reduce neuronal synchrony in Parkinson's disease by adjusting synaptic weights through spike-timing-dependent plasticity.

Differentiating filter-induced oscillations from physiological stimulation-evoked potentials in intracranial recordings

The paper identifies and differentiates filter-induced oscillations from physiological stimulation-evoked potentials in intracranial recordings to improve DBS targeting accuracy.

Generation mechanisms and species-specific properties of parkinsonian beta oscillations in the basal ganglia

The paper evaluates the generation mechanisms of abnormal beta oscillations in the basal ganglia across species using a network model with species-specific parameters.

Deep brain stimulation of the mesencephalic locomotor centre induces stimulation-dependent behavioural states beyond locomotion

This study investigates how different frequencies and amplitudes of DBS in the MLR affect behavior in rats, finding that high-frequency stimulation induces hyperlocomotion and defensive behaviors, while low-frequency stimulation causes immobility.

Depolarization block in substantia nigra pars reticulata neurons drives dystonia in a mouse model

The paper shows that depolarization block in SNr neurons contributes to dystonia in a mouse model by reducing firing during dystonic attacks.

Striatal cholinergic interneuron pathology and muscarinic signaling independently shape motor dysfunction in a DYT-TOR1A dystonia model

This study investigates the role of striatal cholinergic interneuron pathology and muscarinic signaling in dystonia using a mouse model, showing that ChI degeneration contributes to motor dysfunction but is not required for antimuscarinic drug effects.

Spatiotemporal characterization of corticolimbic dopamine and noradrenaline signaling and affective state modulation by mfb stimulation

This study examines how mfb DBS affects dopamine and noradrenaline signaling in specific brain regions and correlates these changes with behavioral responses in rats.

Weak electric fields of deep brain stimulation can entrain spiking in multi-compartment cortical neuron models

This study investigates how weak electric fields from deep brain stimulation (DBS) can modulate cortical neuron spike timing through computational models.

Comparison of Machine Learning Surrogate Models for Prediction of Single-Fiber Activation in Deep Brain Stimulation

This study compares machine learning models for predicting single-fiber activation in DBS across various electrode configurations, finding that CNNs outperform XGBoost in complex fields.

Pallidal beta oscillations underlying locomotor adaptation in Parkinsons disease

This study examines locomotor adaptation deficits in Parkinson's disease by analyzing GPi oscillatory activity during walking, finding that increased beta activity correlates with reduced adaptability.

Inhibitory Evoked Potentials as a Spatially Dependent Intraoperative Marker of Clinical Tremor Reduction

The paper investigates whether quasi-evoked inhibition in Vim neurons correlates with clinical tremor reduction and its dependence on stimulation location.

Impact of Axon Model Complexity on Deep Brain Stimulation: A Comparative Analysis of MRG and Cohen Double-Cable Models

This study compares two axon models to assess how structural and electrophysiological differences affect deep brain stimulation outcomes.

In silico optimization of deep brain stimulation to enhance cognitive control: Improving performance and practicality with a continuous rolling arena

This paper develops a continuous rolling arena framework for optimizing deep brain stimulation using a multi-armed bandit algorithm to improve cognitive control in psychiatric conditions.

Dystonia-associated TorsinA-ΔE mutation induces a gain-of-function interaction with XPO1 via its N-terminal hydrophobic segment

This study identifies an aberrant gain-of-function interaction between TorsinA-ΔE and XPO1 as a mechanism contributing to nucleocytoplasmic transport dysfunction in DYT1 dystonia.

Reduced entropy of subthalamic beta bursts predicts freezing of gait in Parkinsons disease

The paper identifies reduced entropy of subthalamic beta bursts as a predictor of freezing of gait in Parkinson's disease.

Reconciling contradictory models of subthalamic nucleus contributions to basal ganglia beta oscillations

This paper investigates how different neuron models affect simulated basal ganglia beta oscillations, showing that the choice of integrate-and-fire model determines whether the subthalamic nucleus amplifies or suppresses beta oscillations.

Closed-Loop Vibrotactile Neuromodulation for Reducing Tremor-Related Propranolol Use

This paper develops a closed-loop vibrotactile stimulation system to reduce tremor amplitude and propranolol use by modeling a nonmonotonic tremor-vibration relationship.

Network Dynamics and State-Dependent Effects of Electrical Stimulation in Recurrent Excitatory-Inhibitory Populations

This study investigates how electrical stimulation affects neuronal network dynamics, showing state-dependent suppression of beta oscillations and frequency-specific responses.

Assessing the digit organisation of focal hand dystonia using 7T functional MRI

This study uses 7T fMRI to compare digit maps in FHD patients and healthy volunteers before and after BTX treatment, finding disordered maps in FHD patients and changes in pRF sizes post-treatment.

Dendrite-specific synaptic inputs onto dopaminergic SNc neurons

The paper identifies dendrite-specific synaptic inputs onto dopaminergic SNc neurons from STN, PPN, and SNr, revealing distinct functional roles of these inputs.

Parallel Opposing GABAergic Pallidothalamic Pathways

The paper identifies two parallel GPe-to-nRT pathways with opposing effects on thalamic processing, mediated by region-specific KCC2 expression.

Evidence for traveling beta waves in the parkinsonian subthalamic nucleus

The paper finds evidence of traveling beta waves in the subthalamic nucleus of Parkinson's patients using local field potential recordings and a spherical wave model.

Deep Brain Stimulation Microelectrodes as a Source of Human Subcortical RNA: Validation of a Low-Input Transcriptomic Protocol

This paper validates a low-input RNA extraction protocol using DBS microelectrodes to obtain subcortical RNA from post-mortem brains, confirming brain origin and sub-regional cellular identity.

Modeling Parkinsonian Freezing and Deep Brain Stimulation Effects in a Basal Ganglia Network

This study models Parkinsonian freezing and DBS effects in a basal ganglia network using a Dynamic Neural Field model, showing impaired action selection after dopamine depletion and limited DBS efficacy in the framework.

Can we trust subthalamic local field potentials? Geometric and dynamical constraints on the interpretation of extracellular recordings

This paper challenges the assumption that local field potentials (LFPs) universally reflect population activity by showing that their interpretability depends on neuronal morphology and synchronization state in the subthalamic nucleus.