Neurological disorders and treatments

The paper investigates how amantadine affects neural ensembles in hypokinetic and hyperkinetic conditions, finding it modulates action-specific ensembles rather than rebalancing pathway activity.

This paper develops a neural network model to explain frequency-selective deep brain stimulation effects, showing that a boundary equilibrium bifurcation explains both excitatory suppression and GABAergic output changes.

This paper introduces a computational model to understand how deep brain stimulation affects neuronal circuits by considering synaptic properties, connectivity architecture, and circuit motifs.

This study shows that device-embedded accelerometry better tracks Parkinsonian motor states than neural signals during deep brain stimulation.

This paper develops a surrogate-brain approach to optimize thalamic deep brain stimulation for cortical modulation using inferred effective connectivity and control theory.

The paper shows that motor cortex neurons directly excite inhibitory neurons in the substantia nigra pars reticulata, influencing basal ganglia output.

This study shows unilateral striatal deep brain stimulation improves cognitive control similarly to bilateral stimulation in rodents, matching human findings and highlighting potential clinical benefits.

The paper links STN-DBS frequency-tuned beta subband dynamics to speech tempo in Parkinson's disease, suggesting a potential neural marker for speech modulation.

This study quantifies whole-brain E-field distributions from STN-DBS in Parkinson's patients, finding cortical peak magnitudes exceeding typical transcranial stimulation values.

This study identifies right dorsal prefrontal cortical pathways mediating cognitive control improvements from VCVS DBS.

This study examines bandpower and phase-amplitude coupling in the Globus pallidus internus of Parkinson's patients during different locomotor states, finding correlations with clinical motor scores.

This study shows that deep brain stimulation remodels white matter and alters brain-wide functional connectivity in macaques, contributing to its therapeutic effects.

The paper examines oscillatory activity in brain regions involved in motor control, finding distinct beta and theta patterns associated with proactive and reactive inhibition in Parkinson's patients.

This paper introduces a state space switching method for real-time beta burst detection, improving accuracy and reducing latency compared to traditional envelope-based approaches.

This paper develops a patient-calibrated dynamical model and predictive controller for closed-loop deep brain stimulation in Parkinson's disease, showing improved performance over existing control strategies.

This paper introduces a synchronization method using Transcutaneous Electrical Stimulation to align LFP recordings from DBS electrodes with EEG, enabling precise and reliable data alignment across different recording modes.

The paper identifies and maps GABAergic cell clusters in the human rostromedial tegmental nucleus (RMTg) and retrorubral fields (RRF) using immunohistochemistry and anatomical staining.

This study investigates the genetic basis of essential tremor and its comorbidities using Mendelian Randomization, gene enrichment, and structural equation modeling, finding limited genetic overlap and variance explained.

This study evaluates the effects of low-frequency medial septum stimulation on PTZ-induced seizures in rats, finding that 5 Hz stimulation prevents death and reduces seizure generalization.

This paper shows that dopamine and serotonin changes during deep brain stimulation predict symptom relief in treatment-resistant depression.

The paper investigates sex-specific effects of exercise on motor coordination and basal ganglia physiology in mice, finding differential impacts on neural activity and structure in males and females.

This study identifies three functionally distinct STN neuron populations in macaques during a value-based task, showing that two primarily encode stimulus value and precede GPe activity.

The paper identifies distinct dopaminergic neuron populations projecting to the external Globus Pallidus and shows inhibitory control from the tVTA, revealing a disynaptic circuit.

This paper uses GPU-accelerated optimization to identify synaptic reorganization patterns that produce Parkinsonian beta oscillations in a basal ganglia network model.

The paper reveals the external globus pallidus (GPe) as a basal ganglia output hub with distinct subpopulations that mediate specific behaviors through projection-specific circuits.

The paper examines cortico-STN beta coupling in Parkinson's disease, finding it is confined to beta bursts rather than sustained during non-burst periods.

This study shows that optogenetic stimulation of mPFC axons, not midSTR neurons, enhances cognitive control in a rodent Set-Shift task, suggesting mPFC axons are key drivers of DBS therapeutic effects.

This study validates finite element models for directional DBS by comparing experimental measurements with different boundary condition configurations, finding Dirichlet conditions provide higher accuracy in predicting VTA volume.

This study investigates how high-frequency DBS of the thalamic Vim suppresses neuronal firing by analyzing synaptic and network-level mechanisms in patients with essential tremor.