Spinal Cord Injury Research

This study examines how spinal cord injury affects locomotion speed and gait in rats, revealing changes in gait patterns and coordination after injury.

This study examines how adult cats negotiate obstacles after spinal cord injury, finding improved clearance over time with changes in muscle activation and weight distribution.

This study examines CST reorganization in macaques after partial spinal cord injury, showing axonal sprouting and re-direction in both rostral and caudal spinal segments contributing to recovery of finger dexterity.

This study shows that nicotinamide riboside (NR) increases NAD+ levels in the injured spinal cord, protecting tissue and improving locomotor recovery in rats.

The paper tracks functional recovery in zebrafish after spinal cord injury and identifies gait quality as a predictor of regeneration outcomes.

This study shows that multielectrode configurations of transcutaneous spinal cord stimulation improve muscle recruitment selectivity by targeting specific spinal segments.

This study uses a bi-cortical neuroprosthesis to investigate motor program recovery after spinal cord injury in cats, showing that cortical control can be re-established to modulate gait and alleviate foot drag.

This study shows that spinal cord injury leads to epileptiform activity in sensory circuits, causing ectopic bursting in afferent axons and disrupting sensory signaling.

The paper demonstrates that dynamic spinal stimulation enhances corticospinal motor responses by increasing spinal interneuron excitability, even after injury.

This paper shows that probiotic treatment after spinal cord injury improves gut health and respiratory function by reducing inflammation and enhancing neuronal regeneration.

The paper introduces the Tabulae Paralytica, a multimodal atlas of spinal cord injury, revealing biological principles and developing a gene therapy to restore walking in old mice.

This study investigates the effects of low-intensity pulsed ultrasound (LIPUS) on forelimb function recovery in rats with cervical cord injury, showing improved performance with combined LIPUS and Buspirone treatment.

Boldine improves locomotor function and reduces glial activation in a mouse model of spinal cord injury by modulating calcium signaling and gene expression.

This study transplants autologous neural stem cells into Rhesus monkeys with spinal cord injury, showing functional and structural recovery without adverse effects.

This study shows that administering recombinant mouse mast cell protease 6 improves functional recovery after spinal cord injury by reducing demyelination and astrogliosis.

This study shows motor-targeted spinal stimulation can reduce neuropathic pain by decreasing activity in pain pathways while preserving motor function in chronic spinal cord injury.

This study shows that global disinhibition and corticospinal plasticity enable drastic motor recovery after spinal cord injury in macaques through intensive training and cortical electrical stimulation.

This study evaluates the effect of 4-MU on spinal cord injury in rats, showing reduced HA synthesis and glial scar but insufficient functional recovery.

This review evaluates estrogen and estrogenic compounds' neuroprotective effects in spinal cord injury, finding they reduce inflammation and improve functional outcomes.

This study uses single-cell sequencing to analyze the transcriptomic changes in mice with spinal cord injury treated with zinc therapy, identifying immune heterogeneity and potential mechanisms of neuroprotection.

The paper investigates fibrotic scar formation in spinal cord lesion rats over one year and assesses neuronal regeneration through fore paw reaching task performance.

This study shows that delayed AAV1-NT3 injection after spinal injury improves skilled locomotion and swimming coordination in rats but not gross movement.

This study shows spinal stimulation enhances or suppresses muscle activity during voluntary torque tasks in monkeys, depending on torque direction and voluntary muscle activity levels.

The paper uses single-cell RNA sequencing to identify immune cell populations and interactions in mouse spinal cord injury, revealing microglial and B cell heterogeneity and crosstalk.

The paper maps the spatiotemporal gene expression and cell-cell interactions in a mouse model of acute spinal cord injury, identifying key molecular features and cell types involved in early injury response and recovery.

This study combines serotonergic agonist delivery with rehabilitation to improve motor recovery in severely injured rats, showing long-term benefits after treatment cessation.

This study uses computer simulations to investigate whether gait training in spinalized rats leads to stable spinal circuitry recovery, finding that both stabilizing and destabilizing learning strategies result in functional recovery but not necessarily stable circuitry.

This study develops a hydrogel scaffold with surface chemistry that promotes axon outgrowth and hindlimb recovery in spinal cord injury models.