Topic · Molecular Biology · Biochemistry, Genetics and Molecular Biology
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
98 papers
Mehrshad Sadria, Anita T. Layton
The paper develops a computational model of ageing signalling pathways to study interactions among mTORC, AMPK, and SIRT, and their impacts on lifespan and health-span.
Muriel Koehl, Elodie Ladevèze, Caterina Catania…·Djoher Nora Abrous
This study shows that deleting S6K1 in adult mice causes anxiety-like behaviors and learning deficits, linked to reduced hippocampal neurogenesis and neuronal atrophy.
Fatemeh Mazloumi Gavgani, Thomas Karlsson, Ingvild Løberg Tangen…·Aurélia E. Lewis
The paper shows that nuclear p110β in endometrial cancer cells increases rRNA transcription and correlates with tumor progression.
Xiongwen Cao, Alexandra Khitun, Yang Luo…·Sarah A. Slavoff
The paper identifies alt-RPL36 as a novel regulator of PI3K-AKT-mTOR signaling through interaction with TMEM24, showing its role in modulating PI(4,5)P2 levels and cell size.
Mohamed Moustafa-Kamal, Thomas J. Kucharski, Wissal El-Assaad…·Jose G. Teodoro
The paper identifies the mTORC1/S6K/PDCD4/eIF4A axis as critical for determining cell fate during mitotic arrest, showing that disrupting this pathway can enhance the effectiveness of anti-mitotic drugs.
Maíra H. Nagai, Luciana M. Gutiyama, Victor P. S. Xavier…·Bettina Malnic
This study shows that Ric-8B hypomorphism reduces mTORC2 activity in mice, leading to embryonic defects and impaired GPCR/G protein signaling.
Mohammadreza Dorvash, Mohammad Farahmandnia, Pouria Mosaddeghi…·Iman Tavassoly
The paper develops a mathematical model to explain how rapamycin differentially inhibits mTORC1 and mTORC2 based on Le Chatelier's principle.