Hypothalamic control of reproductive hormones

The paper shows that kisspeptin, not other co-transmitters, activates GnRH neuron dendrons, and that its deletion abolishes episodic hormone secretion despite preserved KNDy neuron synchronization.

The paper shows that male mice have nearly as many Kiss1RP3V neurons as females, which can stimulate testosterone synthesis when activated.

The paper identifies Pclo mutations in rats that affect reproductive behavior and link to depression-associated genes.

The paper identifies two spexin paralogs in tilapia that inhibit FSH and LH via Galr2b, revealing their role in the brain-pituitary-gonad axis.

The paper shows that optogenetic stimulation of MePD kisspeptin neurons in female mice increases LH pulse frequency, suggesting their role in regulating the GnRH pulse generator.

This study shows Gli3 is critical for olfactory ensheathing cell development and GnRH-1 neuronal migration, and identifies a GLI3 mutation in a Kallmann syndrome patient.

The paper investigates the role of neuroprogesterone signaling through Src kinase in RP3V neurons to trigger the luteinizing hormone surge in female rats.

The paper identifies ASPHD1 as a key driver of reproductive traits in the 16p11.2 locus using biobank data, Mendelian randomization, and animal models.

This study shows that neuroprogesterone induces the LH surge via RP3V kisspeptin neurons in female rats by restoring the surge when kisspeptin is administered.

This study uses CRISPR-Cas9 to disrupt ER in specific kisspeptin neuron populations in adult mice, revealing distinct roles of AVPV and arcuate kisspeptin neurons in estradiol-mediated negative and positive feedback on GnRH.

This study shows that NKB signaling in the medial amygdala stimulates gonadotropin release in female mice independently of kisspeptin.

This study identifies miR-505-3p as a repressor of puberty onset in female mice, showing delayed puberty and reduced fertility with its overexpression and earlier puberty with its knockout.

This study identifies 78 genetic signals for male puberty timing using a large sample of men, revealing links to hair color and health outcomes.

This study identifies PACAP-expressing neurons in the ventral premammillary nucleus that regulate reproductive function in female mice by modulating kisspeptin neurons.

This study performs a GWAS meta-analysis of menstrual cycle length in European women, confirming the FSHB locus association and identifying four novel signals linked to the HPG axis.

This study identifies 26 genetic loci associated with reproductive ageing in a Japanese population, highlighting differences in allele frequencies and effect estimates compared to European populations.

The paper estimates genetic and environmental influences on testosterone, DHEA, and progesterone concentrations in human hair across 8-18 years in twins, identifying sex-specific heritability peaks.

The paper investigates how stress affects the HPG axis transcriptome in rock doves, finding females show more differential gene expression than males.

This study identifies sex-biased gene expression patterns in the HPG axis of rock doves, revealing tissue-specific differences in reproductive-related genes.

This study shows that proper olfactory bulb development and olfactory/vomeronasal axonal connections are not required for GnRH-1 neuronal migration to the hypothalamus.