Sleep and Wakefulness Research

This paper classifies sleep stages in head-fixed mice using pupil dynamics and an LSTM model, achieving higher accuracy than a feed forward neural network.

The paper shows that presenting positive words during NREM sleep can reduce negative affect judgments of unwanted memories, associated with changes in theta and sigma brain activity.

The paper distinguishes between slow waves and delta waves during NREM sleep, showing type-1 slow waves are homeostatically regulated and linked to down states, while type-2 slow waves confuse the timing of hippocampal sharp-wave ripples.

This study shows that the PFC-VLPO pathway regulates REM sleep fragmentation in response to social defeat stress.

The paper identifies hypothalamic supramammillary neurons projecting to the medial septum as a key circuit for controlling wakefulness through optogenetic and chemogenetic experiments.

The paper investigates how sleep and wake affect parallel fiber synapses in Purkinje cells, finding that sleep increases 'naked' spines and alters branched synapse dynamics.

This study investigates how early life sleep disruption affects later sleep patterns in prairie voles, finding sex-specific changes in REM and NREM sleep in adulthood.

This study investigates the characteristics of cued memory reactivation during sleep and identifies optimal cue timing for enhancing memory through targeted reactivation.

The paper develops a sleep-based metric to quantify brain maturation using EEG data from children, showing high accuracy in predicting chronological age and detecting neurodevelopmental differences.

Wearing an eye mask during sleep improves episodic memory and alertness the next day, with benefits linked to increased slow wave sleep.

This study examines how pupil diameter and blinking correlate with cortical activity and hemodynamics across different arousal states in mice, finding strong relationships that can reliably indicate arousal state.

This study shows that increasing cAMP levels in hippocampal neurons during sleep deprivation prevents deficits in long-term potentiation, indicating cAMP signaling mediates sleep loss effects on synaptic plasticity.

This study evaluates the efficacy of TAK-925 and ARN-776, HCRTR2 agonists, in reducing cataplexy and promoting wakefulness in narcoleptic mice.

This study investigates whether sleep spindle activity supports consolidation of motor skills learned through physical practice, motor imagery, and action observation, finding a common spindle organization but distinct outcomes.

This study uses machine learning to predict sleep-related genes from genomic data and validates the NF-κB pathway's role in sleep duration in mice.

The paper shows that combining wakeful training with sleep-based memory reactivation enhances positive self-referential processing.

This study examines the effect of daytime naps on word learning in children and adults, finding naps maintain explicit memory but no lexical integration, with white matter correlates in children.

The paper investigates memory consolidation during sleep by reactivating memories with sounds and measuring electrophysiological responses, finding gamma band activity correlates with memory improvement.

The paper proposes a mathematical model of astrocytic sleep-awake homeostasis that explains the regulation of sleep pressure and synaptic strength dynamics through feedback control loops.

The paper identifies pallidin, a BLOC-1 gene, as upregulated in mice lacking histamine and orexin, associated with sleep disorders and altered neurotransmitter systems.

This study analyzes EEG brain state distribution and connectivity in SYNGAP1 mutant rats, finding altered state dynamics and reduced connectivity during sleep spindles.

This study examines theta oscillations (4-8 Hz) in EEG during cognitive tasks and sleep deprivation, finding differences in topography but suggesting a common mechanism.

This study quantifies sleep EEG changes in a SCA3 mouse model, finding increased REM duration, beta power, and spectral alterations in homozygous mice compared to wild-type.

The paper shows that N1 sleep leads to more memory forgetting compared to N2 sleep, with alpha/theta power ratio linked to forgetting rates.

This study shows that increased non-rapid eye movement (NREM) sleep in the prefrontal cortex is necessary and sufficient for promoting resilience to social stress in mice.

This study shows that acute sleep deprivation alters neuromuscular junction structure and function in rat soleus muscle, with partial recovery after sleep restoration.

The paper develops an automated system for Targeted Memory Reactivation during sleep and shows it can improve spatial memory when stimulus intensity is controlled.

This study shows that acute hyper- and hypoglycemia disrupt the metabolic cooperation between glucose and lactate in the brain, affecting sleep-wake cycles.

The paper analyzes sleep spindle activity in human anterior thalamus and cortex using EEG and DBS recordings, finding coordinated patterns and frequency-dependent topography.

This study uses intrathalamic recordings to show that different thalamic nuclei coordinate neocortical oscillations during NREM sleep in humans, with distinct timing relationships between thalamic and cortical slow oscillations and spindles.