Sleep and Wakefulness Research

This study investigates delta waves, spindles, and slow oscillations in human NREM sleep and their role in memory formation in older adults, finding that the ratio of SO- to delta-nested spindles predicts memory ability.

This study investigates how estradiol affects adenosinergic signaling and NREM sleep need in adult female rats, finding that estradiol increases extracellular adenosine and blocks A2A receptor effects in the MnPO.

The paper identifies two types of slow waves in human sleep, slow switchers and fast switchers, and shows aging is associated with reduced connectivity and faster dissipation of sleep pressure.

This study develops an optogenetic model of stroke in mice to investigate its effects on sleep patterns and cognition, finding impaired sleep stability and cognitive function.

This study identifies 1,146 dysregulated genes in the hippocampus following acute sleep deprivation, revealing distinct transcriptomic changes in RNA splicing, cell adhesion, and synaptic processes.

The paper investigates how sleep affects memory for graph networks, finding that sleep enhances retention of links between highly connected nodes.

This study shows that silencing specific cortical neurons in mice increases wakefulness and reduces sleep rebound after deprivation, highlighting the cortex's role in sleep regulation.

This study examines how a schizophrenia-associated ZNF804A variant affects sleep neurophysiology and memory consolidation in healthy adults.

This study investigates sleep and thalamo-cortical network dynamics in a mouse model of redox dysregulation linked to schizophrenia, finding disrupted sleep architecture and homeostasis.

This study shows that sleep deprivation reduces specific spine types on certain dendritic branches in CA1 neurons, but not others, suggesting branch-specific effects on structural plasticity.

The paper shows that limb twitches in human infants during quiet sleep synchronize with sleep spindles and increase with age, indicating developing functional connectivity in sensorimotor networks.

The paper finds that high dream recallers show larger ERP amplitudes for both bottom-up and top-down attentional processes during passive listening, suggesting enhanced attentional mechanisms without affecting behavioral performance.

This study shows that playing relaxing words during sleep increases slow-wave sleep duration and quality, suggesting mental concept activation influences sleep depth.

This study examines how bicuculline infusion into specific preoptic nuclei of lactating rats affects sleep and maternal behaviors, revealing distinct effects on active maternal care and wakefulness.

The paper shows REM and NREM sleep abnormalities and structural changes in GBA1 mice, linking them to RBD and alpha-synucleinopathy progression.

This study shows that endogenous memory reactivation during sleep is linked to slow oscillation spindle complexes and predicts memory consolidation in humans.

The paper proposes that REM sleep and neuroplasticity co-evolve to defend the visual cortex from takeover by other sensory systems.

This study shows that astrocyte Ca2+ levels change with sleep/wakefulness states and vary across brain regions in mice.

This study examines how hippocampal sharp-wave ripples and slow-waves interact to coordinate neural activity during sleep in humans.

The paper investigates how sleep loss affects ribosome-associated transcripts in specific brain regions and cell types, finding region- and cell type-specific changes in transcripts related to synaptic plasticity and cellular timekeeping.

The paper identifies distinct subtypes of slow wave and spindle coupling during sleep across the human lifespan and shows their composition shifts with age.

The paper shows that intraneuronal chloride levels increase with wakefulness, reducing synaptic inhibition and affecting cortical function, and that targeting chloride can restore performance in tired states.

This study investigates how brainstem cholinergic neurons modulate thalamic activity and cortical sleep stages in anesthetized mice using optogenetic techniques.

This study examines sleep spindles and slow oscillations in pre-school children to assess their role in memory consolidation, finding two distinct spindle types with differential associations with memory quality.

This study maps cortical and subcortical hemodynamic changes during human sleep slow waves using EEG-fMRI recordings, showing regional BOLD signal fluctuations linked to slow wave propagation and functional connectivity.

The paper shows sleep enhances spatial memory consolidation in both rats and humans through system-wide neural changes, regardless of training type.

This study investigates the role of mGluR5 in memory processing during sleep and finds that blocking mGluR5 does not affect memory consolidation despite altering sleep oscillations.

This study identifies reciprocal GABAergic projections between the lateral hypothalamus and dorsal raphe nucleus that promote wakefulness through mutual inhibition and network activity modulation.

The paper tests if basal forebrain parvalbumin neurons modulate vigilant attention in mice using optogenetic methods and finds they improve reaction times and rescue deficits from sleep deprivation.

This study investigates the relationship between fasting-induced torpor, sleep, and wakefulness in mice by analyzing EEG, EMG, and body temperature data.