Sleep and Wakefulness Research

This study investigates sleep function in Drosophila melanogaster, finding that sleep restriction is not lethal and that circadian drive, not homeostasis, primarily drives sleep pressure.

This paper identifies BOLD oscillations in fMRI that differentiate sleep from wake and correlate with spindles and slow waves.

This study identifies REM sleep as a core response to chronic stress in mice, linking it to corticosterone regulation and apoptotic pathways through transcriptomic analysis.

The paper examines how neuronal firing rates change during REM and NREM sleep in rats, finding increased variance during REM and homogenization during NREM.

The paper identifies 122 novel sleep-related genes from a large-scale knockout mouse study using non-invasive sleep monitoring.

The paper identifies genetic risk variants associated with vaccination-related narcolepsy using genomic data from cases and controls.

This paper shows that AMPK signaling, disrupted by the 1q21.1 deletion, is essential for neuronal integrity, sleep maintenance, and stress survival in Drosophila.

This study shows that sleep deprivation increases food reward valuation through hedonic mechanisms, not hormonal changes, using fMRI and behavioral tasks.

The paper examines how sleep affects the retention of negative and neutral memories, finding that sleep selectively stabilizes negative contextual memories.

This paper introduces a new classification of NREM sleep stages in mice, revealing human-like stages and their association with neuronal activity changes.

The paper analyzes how auditory cues during slow-wave sleep affect brain network connectivity and memory stabilization.

This paper develops a brain-based sleep scoring method using olfactory bulb and hippocampal oscillations in mice, achieving high accuracy comparable to EMG and video tracking.

The paper investigates whether sleep or training variability affects motor adaptation consolidation, finding that higher training variability improves retest performance, correlating with alpha power in parietal areas.

The paper tests if targeted memory reactivation during sleep can improve memory for object pairs, finding better recall for cued objects than non-cued ones.

This study examines how disrupting the Hcrtr1 gene in noradrenergic neurons affects theta and gamma oscillations in different arousal contexts, revealing context-dependent changes in brain activity.

The paper shows that memory reactivation patterns reoccur during NREM sleep at a 1 Hz slow oscillatory rhythm, coordinated by theta oscillations.

This paper introduces PiezoSleep, a noninvasive method to detect sleep/wake in narcoleptic mice, showing it can identify phenotypes and screen drugs efficiently.

The paper identifies theta bursts preceding and spindles following cortical and thalamic downstates in human NREM sleep, suggesting theta bursts may trigger downstates and aid memory consolidation.

The paper shows that specific visual features, like Gabor orientation, are reactivated in human V1 after visual training, and this reactivation correlates with performance improvement.

The paper characterizes the spatial and temporal dynamics of slow oscillation-spindle coupling during sleep and finds individual variability in coupling phase that is stable across nights but not linked to memory change.

This study identifies a basal ganglia circuit involving SNr and STN neurons that regulates sleep and motor control by modulating behavioral transitions.

The paper examines how information flow between brain regions changes during non-REM sleep in rats, finding that task-related neurons show increased short-time communication while non-task neurons show increased long-time communication.

This study examines how dream report collection and task incorporation during sleep affect memory consolidation, finding that NREM sleep dreams are linked to improved task performance.

This study shows that memory consolidation during sleep involves competition and selective weakening, with beta power indicating competition-based forgetting and sigma power indicating memory strengthening.

This study shows that REM sleep deprivation in rats increases ROS levels and oxidative stress in hepatocytes, with elevated iNOS and NO, which normalize after recovery sleep.

This study characterizes electrophysiological properties and MCH/HO neuronal distribution in the lateral hypothalamus of naked mole-rats, finding similarities to mice but distinct distribution patterns.

This study finds that narcolepsy type 1 patients show increased brain activation to neutral-rated movies compared to controls, suggesting altered humor processing and potential links to cataplexy mechanisms.

This study identifies genetic risk loci for narcolepsy, showing enrichment in immune cells and suggesting autoimmune modulation via T cell receptor chains and influenza-A infection.

This study shows sleep spindles and slow oscillations each play distinct roles in memory consolidation, with spindles enabling independent memory replay and slow oscillations favoring strong memories, as observed in natural sleep.

The paper investigates how overnight memory consolidation affects new learning of similar materials, finding that consolidation facilitates rather than interferes with learning, and that D-cycloserine enhances new learning independently of sleep.