Sleep and Wakefulness Research

This study investigates how sleep deprivation affects gene expression and nuclear protein abundance in neurons and astrocytes using integrated transcriptomics and proteomics.

This study identifies mitochondrial respiration and ATP synthesis as key factors in sleep regulation by analyzing single-cell transcriptomes in sleep-deprived flies.

This study shows that temperament modulates the effects of sleep deprivation on mood-related behaviors and neurobiological markers in rats.

The paper identifies ultraslow serotonin oscillations in the hippocampus that distinguish substates within NREM and waking, linking them to memory consolidation and arousal.

The paper investigates how stress affects activity levels through interactions between orexin neurons and astrocytes, finding that astrocytic glucocorticoid receptors mediate sex-specific changes in neuronal firing and activity.

This study identifies orexinergic projections to the substantia innominata as critical for arousal and analgesia, showing their modulation by anesthesia and OX2R-mediated effects.

This study shows that pre-sleep audiobooks influence neural activity and dream content during REM sleep, with beta power and neural reinstatement linked to memory performance.

This study shows that high-intensity exercise before sleep enhances memory encoding the next morning, with effects lasting up to 24 hours.

This study shows that inflammatory pain in mice alters sleep architecture and circadian rhythms, with effects dependent on the light cycle.

This study examines sleep patterns in Mecp2-/y mice, finding time-of-day-dependent sleep alterations and worsened sleep architecture after sleep deprivation.

The paper investigates abrupt and gradual changes in neuronal processing during sleep onset and awakening in rats, finding abrupt increases in silent periods and gradual increases in population synchrony.

This study investigates sex-dependent sleep patterns in response to social-defeat stress in mice, finding differences in NREM and REM sleep that correlate with stress resilience.

The paper identifies a new class of high-frequency brain oscillations (25-35 Hz) called 'iota' that occur during wakefulness and REM sleep but not NREM sleep, more frequently in children than adults.

This study examines how sleep deprivation affects EEG spectral measures, finding that spectral slope indicates sleep depth changes and spindle frequency dynamics shift during recovery sleep.

The paper analyzes RNA-seq data from sleep-deprived and recovery sleep mice to identify gene expression changes linked to sleep homeostasis and SD effects.

This study shows that excitatory brain stimulation before sleep increases spindle activity in the stimulated cortical regions during sleep, indicating spindles can be directed by external excitation.

This study examines the effects of one-night partial sleep deprivation on perivascular space volume fraction using the Stockholm Sleepy Brain Study, finding no significant overall association but some interactions that did not survive multiple comparisons.

This study identifies electrophysiological correlates of lucid dreaming using EEG data from multiple labs, finding source-level changes in gamma1 and alpha power.

This study shows that CB-1 receptor agonist alters sleep oscillatory activity in rats, changing theta and spindle patterns and affecting sleep state transitions.

This study examines how resting-state functional connectivity and sleep spindle dynamics influence memory consolidation in older adults, finding that reduced brain network specialization is linked to poorer memory consolidation.

This study investigates sleep homeostasis in lizards, finding a rebound in local field potential after sleep deprivation and a role for the cortex in regulating sleep-related activity rebounds.

The paper compares heartbeat-related neural activity in the anterior thalamus during phasic and tonic REM sleep and wakefulness, finding distinct patterns in phasic REM.

This study examines how habitual sleep quality affects episodic memory using EEG-based representational similarity analysis, finding mixed correlations between sleep metrics and memory performance.

The paper identifies orexin-sensitive layer 6 neurons in the prefrontal cortex that regulate cortical excitability and anxiety behaviour.

This study shows serotonin modulates infraslow oscillations in the dentate gyrus during NREM sleep, influencing memory through 5-HT1a receptors.

SleepInvestigatoR streamlines sleep analysis in rodents by automating calculations and visualization of sleep metrics from scored files.

This paper reviews 69 studies on dream recall after awakening from different sleep stages, finding that awakening method, sleep environment, and participant characteristics significantly affect recall rates.

This study shows that trazodone increases NREM sleep and delta power in mice, replicating its effects in humans, using a novel voluntary oral administration protocol.

This study compares functional connectivity and spatiotemporal dynamics in individuals with idiopathic hypersomnia, narcolepsy type 1, and healthy controls, finding significant differences in key networks post-nap.

This study finds a significant association between slow-wave sleep duration and nucleus accumbens volume in older adults.