Sleep and Wakefulness Research

The paper investigates sex-dependent effects of NLGN2 absence on sleep and wake states, finding distinct transcriptome and proteome changes in male and female mice.

The paper examines differences in twitching and twitch-spindle coupling between N2 and N3 sleep in 6-month-olds, finding distinct patterns in twitch intensity and coupling despite similar spindle characteristics.

This study identifies a thalamic hub that integrates brainstem and stress signals to regulate REM sleep through activity-dependent modulation of theta oscillations.

This study identifies mitochondrial respiration and ATP synthesis as key factors in sleep regulation by analyzing single-cell transcriptomes in sleep-deprived flies.

This study shows that temperament modulates the effects of sleep deprivation on mood-related behaviors and neurobiological markers in rats.

The paper identifies ultraslow serotonin oscillations in the hippocampus that distinguish substates within NREM and waking, linking them to memory consolidation and arousal.

This study identifies GABA neurons in the SLD nucleus as suppressors of wakefulness, showing their role in sleep-wake regulation and their pathological involvement in narcolepsy.

The paper investigates how stress affects activity levels through interactions between orexin neurons and astrocytes, finding that astrocytic glucocorticoid receptors mediate sex-specific changes in neuronal firing and activity.

This study identifies orexinergic projections to the substantia innominata as critical for arousal and analgesia, showing their modulation by anesthesia and OX2R-mediated effects.

This study shows that pre-sleep audiobooks influence neural activity and dream content during REM sleep, with beta power and neural reinstatement linked to memory performance.

This study shows that high-intensity exercise before sleep enhances memory encoding the next morning, with effects lasting up to 24 hours.

This study shows that light-induced sleep in mice requires histamine neurotransmission, as demonstrated by reduced sleep responses in HDC knockout and chemogenetically silenced mice.

This study shows that a constitutively active form of Unc13A reduces sleep rebound after deprivation, suggesting a role for SNARE complex dynamics in sleep homeostasis.

This paper shows that slow-wave sleep interleaves replay of familiar and novel memory traces, enabling new memories to integrate into existing cortical memory without interference.

This study shows that inflammatory pain in mice alters sleep architecture and circadian rhythms, with effects dependent on the light cycle.

This study shows that slow-wave sleep reduces CSF concentrations of beta-amyloid and tau in healthy adults, suggesting enhanced CSF turnover during sleep.

The paper examines how sound processing in the auditory cortex changes during slow wave sleep compared to wakefulness, finding that sound representations remain geometrically distinct but are dampened and intermittently gated.

The paper shows that sleep enhances successor representations of learned sequences, with stronger memory performance linked to increased slow-wave sleep.

This study examines sleep patterns in Mecp2-/y mice, finding time-of-day-dependent sleep alterations and worsened sleep architecture after sleep deprivation.

This study examines how napping affects functional brain responses in older adults during a working memory task, finding differences in brain activity and performance between nappers and non-nappers.

This study investigates the role of the paraventricular nucleus of the thalamus (PVT) in sleep disturbances during ethanol withdrawal, finding that aPVT neuronal activity and KCNQ2 expression are critical in regulating sleep patterns.

This study investigates how APOE genotype affects sleep architecture, finding that APOE4 homozygotes have higher arousal thresholds and reduced sleep spindle activity.

The paper investigates abrupt and gradual changes in neuronal processing during sleep onset and awakening in rats, finding abrupt increases in silent periods and gradual increases in population synchrony.

The paper identifies EEG features distinguishing idiopathic hypersomnia from controls using sleep microarchitecture and hypnodensity metrics.

This study investigates the neural correlates of dream recall frequency using multimodal neuroimaging in 258 individuals, finding associations between DRF and brain structure and function.

This study identifies spatiotemporal sleep spindle clusters in aging and finds age-related changes in their expression and association with memory performance.

This study investigates sex-dependent sleep patterns in response to social-defeat stress in mice, finding differences in NREM and REM sleep that correlate with stress resilience.

The paper identifies a new class of high-frequency brain oscillations (25-35 Hz) called 'iota' that occur during wakefulness and REM sleep but not NREM sleep, more frequently in children than adults.

Auditory stimulation during sleep increases slow oscillations and SO-spindle complexes, which correlate with improved memory consolidation in children with epilepsy and controls.

This study examines how sleep deprivation affects EEG spectral measures, finding that spectral slope indicates sleep depth changes and spindle frequency dynamics shift during recovery sleep.