Ion Channels and Receptors

Disruption of Glial Ca2+ Oscillations at the Drosophila Blood-Brain Barrier Predisposes to Seizure-Like Behavior

The paper shows disruption of Ca2+ oscillations in Drosophila perineurial glia leads to seizure-like behavior without affecting BBB structure.

Unique molecular characteristics of visceral afferents arising from different levels of the neuraxis: location of afferent somata predicts function and stimulus detection modalities

The paper uses molecular profiling to show that visceral afferents from different ganglia have distinct gene expression patterns, indicating functional specialization and integration of sensory information.

Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics

The paper develops ER lumenal Ca2+ sensors in Drosophila to study how HSP-related mutations affect ER calcium dynamics in motor neurons.

Keratinocytes are required for normal cold and heat sensation

This study shows keratinocytes are essential for normal cold and heat sensation in mammals through calcium release and ATP-P2X4 signaling.

Enhanced sensory coding in mouse vibrissal and visual cortex through TRPA1

This study shows TRPA1 enhances sensory processing in mouse vibrissal and visual cortex by modulating neuronal activity and signal encoding.

Genetic Deletion of TrpV1 and TrpA1 Does not Alter Avoidance of or Patterns of Brainstem Activation to Citric Acid in Mice

The paper shows that TrpV1 and TrpA1 deletion does not affect acid avoidance behavior or brainstem activation patterns to citric acid in mice with intact taste systems.

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

This study investigates two TRPM3 mutations linked to DEE, showing they cause gain of function through altered channel gating and increased sensitivity to neurosteroids and heat.

Capsaicin and its analogues impede nocifensive response of Caenorhabditis elegans to noxious heat

This study shows capsaicin and its analogues reduce nocifensive response in C. elegans to noxious heat, with effects reversing after 6 hours.

A single TRPV1 amino acid controls species sensitivity to capsaicin

The paper identifies a single amino acid substitution in TRPV1 that determines species sensitivity to capsaicin between birds and mammals.

Upregulation of TRPM3 drives hyperexcitability in nociceptors innervating inflamed tissue.

This study shows that TRPM3 upregulation in nociceptors contributes to heat hyperalgesia during inflammation, with pharmacological inhibition reducing TRPV1 and TRPA1 responses.

Disease-associated mutations in TRPM3 render the channel overactive via two distinct mechanisms

The paper shows two disease-associated TRPM3 mutations cause overactivity through distinct mechanisms, with potential therapeutic implications using primidone.

Gi-Coupled Receptor Activation Potentiates Piezo2 Currents via Gβγ

This study shows that Gi-coupled receptor activation enhances Piezo2 currents through Gβγ signaling in DRG neurons and heterologous systems.

Alternative splicing switches STIM1 targeting to specialized membrane contact sites and modifies SOCE

This study identifies a spliced variant of STIM1, Stim1A, which alters its localization and function in SOCE, adapting Ca2+ entry to specific cellular contexts.

The sensory coding of warm perception

The paper shows mice can discriminate warm temperatures without dedicated thermoreceptors, using polymodal C-fibers and central circuits that integrate inputs from multiple afferents.

β11-12 linker isomerization governs Acid-sensing ion channel desensitization and recovery

The paper investigates the role of β11-12 linker isomerization in ASIC desensitization and recovery using electrophysiology, simulations, and cross-linking.

Mechanoreceptor-mediated circuit regulates cold tolerance in Caenorhabditis elegans

The paper shows that mechanoreceptor-mediated circuits in C. elegans regulate cold tolerance through temperature sensing via DEG-1 channels in specific neurons.

TMEM184b is necessary for IL-31 induced itch

This study identifies Tmem184b as essential for IL-31-induced itch by regulating pruriceptive gene expression and Wnt signaling in DRG neurons.

TRPV2 activation reorganizes actin cytoskeleton, induces neurite initiation and branching by altering cAMP levels

This study shows TRPV2 activation affects actin cytoskeleton and induces neurite initiation and branching through cAMP level changes in F11 cells.

Drosophila menthol sensitivity and the Precambrian origins of TRP-dependent chemosensation

The paper investigates menthol sensitivity in Drosophila using TRP channels, finding conserved roles in nociception and suggesting ancient origins of TRP-menthol sensing.

Progressive recruitment of distal MEC-4 channels determines touch response strength in C. elegans

The paper shows that stronger touch stimuli recruit more distant mechano-electrical transduction channels in C. elegans, increasing touch response amplitude and kinetics.

Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6

This study identifies Trpv6 as a regulator of epithelial cell quiescence by maintaining Ca2+ influx and suppressing growth factor signaling.

MRGPRX4 is a novel bile acid receptor in cholestatic itch

The paper identifies MRGPRX4 as a novel bile acid receptor involved in cholestatic itch, showing its activation by bile acids and its role in itch induction in humans.

HESC-derived sensory neurons reveal an unexpected role for PIEZO2 in nociceptor mechanotransduction

The paper generates hESC-derived nociceptor-like cells and shows they exhibit mechano-nociceptive characteristics requiring PIEZO2 for mechanotransduction.

Drosophila Trpm mediates calcium influx during egg activation

The paper identifies Trpm as the critical ion channel mediating calcium influx during Drosophila egg activation, showing its conservation with mouse Trpm in calcium signaling.

It takes two vanilloid ligand bindings per channel to transduce painful capsaicin stimuli

The paper shows that two vanilloid ligand bindings per TRPV1 channel are sufficient for maximal pain signaling, revealing how TRPV1 integrates pain signals from multiple stimuli.

Tetrodotoxin-sensitive sodium channels mediate action potential firing and excitability in menthol-sensitive Vglut3-lineage sensory neurons

Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation

The paper shows that Gαq inhibits TRPM8 by reducing its affinity for PI(4,5)P2, making it more sensitive to PI(4,5)P2 depletion upon GPCR activation.

A labeled-line for cold from the periphery to the parabrachial nucleus

The paper identifies a cold-specific neural pathway from the periphery to the parabrachial nucleus, characterized by unique physiological and connectivity properties.

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late phase formalin response

This study identifies a Trpa1 splice junction variant in Diversity Outbred mice that influences late phase formalin response, linking it to pain sensitivity mechanisms.

Oral thermosensing by murine trigeminal neurons:modulation by capsaicin, menthol, and mustard oil

The paper investigates how mouse trigeminal neurons respond to thermal and chemesthetic stimuli, finding that these neurons respond to cool, warm, and nociceptive temperatures, and that chemesthetic compounds modulate their responses.