Ion Channels and Receptors

A labeled-line for cold from the periphery to the parabrachial nucleus

The paper identifies a cold-specific neural pathway from the periphery to the parabrachial nucleus, characterized by unique physiological and connectivity properties.

Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late phase formalin response

This study identifies a Trpa1 splice junction variant in Diversity Outbred mice that influences late phase formalin response, linking it to pain sensitivity mechanisms.

Oral thermosensing by murine trigeminal neurons:modulation by capsaicin, menthol, and mustard oil

The paper investigates how mouse trigeminal neurons respond to thermal and chemesthetic stimuli, finding that these neurons respond to cool, warm, and nociceptive temperatures, and that chemesthetic compounds modulate their responses.

Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity

This study engineers RTx sensitivity in TRPV3 by mutating residues corresponding to the TRPV1 vanilloid site and shows that activation requires additional factors like pore mutations or co-agonists.

Magnetic Entropy as a Gating Mechanism for Magnetogenetic Ion Channels

The paper proposes that magnetic fields can alter the magnetic entropy of biogenic nanoparticles, potentially triggering temperature-sensitive ion channels to create magnetogenetic effects.

Single cell q-PCR derived expression profiles of identified sensory neurons

The paper uses single cell qPCR and functional assays to correlate gene expression with functional properties in identified sensory neurons, finding transcriptional heterogeneity within functional subgroups.

Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure

This study shows that PKD2 channels in arterial smooth muscle cells regulate blood pressure and that their removal lowers blood pressure and prevents hypertension-related arterial remodeling.

TRPC3 is essential for functional heterogeneity of cerebellar Purkinje cells

This study shows TRPC3 is essential for functional heterogeneity in cerebellar Purkinje cells by affecting simple and complex spike activity and behavior related to specific modules.

Simultaneous Deletion of Transient Receptor Potential Vanilloid 3 and Cacna1h Undermines Ca2+ Homeostasis in Oocytes and Fertility in Mice

This study shows that simultaneous deletion of TRPV3 and CaV3.2 channels in mice leads to subfertility and impaired Ca2+ homeostasis in oocytes and eggs.

Inositol 1,4,5-trisphosphate receptor type2-independent Ca2+ release from the endoplasmic reticulum in astrocytes

The paper re-evaluates Ca2+ release from the ER in IP3R2-KO astrocytes using imaging and finds attenuated but significant ER Ca2+ release independent of IP3R2.

Pooled functional genomic screens for intracellular calcium effectors

The paper introduces cal-Seq, a pooled knockdown screen using CaMPARI to identify calcium handling genes, finding GPR99 as a regulator of histamine-induced calcium signaling.

Transient Magnetothermal Neuronal Silencing using the Chloride Channel Anoctamin1 (TMEM16A)

This paper demonstrates a method to transiently silence neurons using magnetic nanoparticle heating and temperature-sensitive chloride channels, achieving over 80% suppression of action potential firing.

S1PR3 mediates itch and pain via distinct TRP channel-dependent pathways

This study identifies distinct TRP channel-dependent pathways through which S1PR3 mediates itch and pain in mice.

TACAN is an essential component of the mechanosensitive ion channel responsible for pain sensing

The paper identifies TACAN as an essential subunit of the mechanosensitive ion channel responsible for mechanical pain sensing.

Naked mole-rat cortical neurons are resistant to acid-induced cell death

This study compares acid-induced cell death resistance between naked mole-rat and mouse cortical neurons, finding NMR neurons are more resistant due to smaller ASIC currents and reduced NaV activity.

TRPV1 regulates opioid analgesia during inflammation

The paper shows TRPV1 channels enhance opioid analgesia during inflammation by promoting beta-arrestin2 nuclear translocation, preventing receptor desensitization.

Evaluation of TRPM8 and TRPA1 participation in dental pulp sensitivity to cold stimulation

This study evaluates TRPM8 and TRPA1 receptor expression and function in dental pulp sensory neurons and their role in cold sensitivity, finding that cold perception is independent of these receptors.

Large scale in vivo recording of sensory neuron activity with GCaMP6

This paper demonstrates a technique to monitor large-scale sensory neuron activity in vivo using GCaMP6, revealing polymodality and sensitization in nociceptors under inflammatory conditions.

Naked mole-rat acid-sensing ion channel 3 forms non-functional homomers, but functional heteromers

This study shows that naked mole-rat ASIC3 forms non-functional homomers but functional heteromers with other ASIC subunits, explaining its insensitivity to acid.

A core signaling mechanism at the origin of animal nociception

The paper identifies a conserved TRPA1-mediated signaling mechanism for noxious heat detection across diverse animals, including planarians and humans.

Regulation of somatosensory mechanotransduction by Annexin A6

This study identifies Annexin A6 as a modulator of somatosensory mechanotransduction by affecting mechanically-activated currents in sensory neurons.