Ion Channels and Receptors

Identification of PUFA interaction site on ASIC3 suggests a complex regulatory mechanism

The paper identifies a PUFA binding site on ASIC3 using MD simulations and electrophysiology, showing how DHA modulates channel gating and desensitization.

Molecular and Functional Analysis of Calcium Binding by a Cancer-linked Calreticulin Mutant

The paper analyzes calcium binding properties of a cancer-linked calreticulin mutant and shows it retains low-affinity calcium binding and maintains ER calcium homeostasis.

Junctional Nanodomains Organised by Extended Synaptotagmin-1 Underlie Inflammatory Signalling in Sensory Neurons

This study identifies Esyt1 as a scaffold organizing ER-PM nanodomains that regulate inflammatory pain signaling through Ca2+-dependent interactions.

Structural Mechanism of TRPC3 Channel Activation by the Moonwalker Mutation

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

Macrophage calcium signaling dynamics revealed using genetically-encoded sensors

This study uses genetic biosensors to visualize calcium signaling dynamics in macrophages, revealing mechanosensitivity and the effects of Piezo1 channel ablation.

Orai1α and Orai1β more potently promote NFAT activation and transcription than Orai2 and Orai3

The paper compares the ability of different Orai isoforms to promote NFAT activation and transcription, finding Orai1α and Orai1β are more potent than Orai2 and Orai3.

STIM1 at the plasma membrane: A novel Molecular regulator of B cell migration.

This study identifies STIM1 at the plasma membrane (STIM1PM) as a novel regulator of B cell migration, independent of SOCE, by controlling constitutive calcium entry and intercellular interactions.

Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes Independent of Membrane Trafficking.

This study shows Syntaxin11 primes Orai1 for CRAC channel function, affecting T cell cytotoxicity and gene expression without impacting membrane trafficking.

Temperature-responsive contacts in TRPV1 concentrate in the cytoplasmic coupling domains

This study identifies the cytoplasmic coupling domains of TRPV1 as the temperature-responsive region using simulations and analysis of contact networks.

Yoda molecules agonize PIEZO2

This study shows Yoda1 agonizes PIEZO2 with efficacy similar to PIEZO1 but distinct effects on calcium influx and inactivation kinetics.

Chemically diverse antagonists inhibit human TRPV1 through ligand-specific interaction networks

The paper identifies how diverse TRPV1 antagonists interact with the receptor through different binding modes and highlights conserved inhibited states.

Myelinated mechano-nociceptors encode noxious cold and underlie hypersensitivity in pulpitis

This study identifies myelinated high threshold-mechanonociceptors as the neural basis for tooth cold sensitivity and shows their role in hypersensitivity during pulpitis.

CONSTITUTIVE STIM1L DELETION ALTERS STORE-OPERATED CALCIUM ENTRY KINETICS BUT DOES NOT PERTURB THE DEVELOPMENT AND FUNCTION OF MOUSE SKELETAL MUSCLE

This study shows that constitutive STIM1L deletion in mice alters SOCE activation kinetics in myotubes but does not affect skeletal muscle development or function.

Molecular determinants of ligand recognition and efficacy in the TRPM3 voltage sensor-like domain

This study identifies molecular determinants of ligand recognition and efficacy in TRPM3's voltage sensor-like domain using a combination of structural and functional analyses.

Direct voltage imaging of peripheral axons in vivo reveals ongoing nociceptor firing in healthy mice

The paper uses voltage imaging to show ongoing action potential firing in nociceptor terminals in healthy mice, revealing electrical activity in peripheral axons.

PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons

This study shows PKD2L1 channels in the apical process of CSFcNs are sensitive to pH changes, modulating neuronal excitability through both phasic and sustained currents.

Inflammatory burning pain depends on a specific line of nociceptors

The paper identifies MSK1's role in TRPV1 upregulation in specific nociceptors, linking it to inflammatory pain and heat hyperalgesia.

The functional diversification of somatosensory neuron repertoires across Mammalia

The paper shows that somatosensory neuron repertoires in mammals diversify through changes to conserved neuron types, enabling adaptation to different habitats and body forms.

Chemical transfection reagents induce intracellular Ca2+ signals in TRPA1-expressing cells

This study shows that chemical transfection reagents alter intracellular Ca2+ signaling and TRPA1 activity in different cell types through TRPA1-dependent and -independent mechanisms.

TRPM2 is a direct pain transducer

This study identifies neuronal TRPM2 as a direct pain transducer that mediates acute and chronic pain independently of immune TRPM2 and inflammation.

Antibiotics modulate activity of mouse and human dorsal root ganglia neurons

The paper shows that antibiotics like β-lactams, macrolides, and tetracyclines alter calcium flux in DRG neurons through mechanisms involving extracellular calcium, TRPA1, and mitochondrial ROS.

Cortical TRPV1 modulates sensory processing through TRPA1-dependent mechanisms

This study shows that cortical TRPV1 modulates tactile perception and sensory processing in mice through TRPA1-dependent mechanisms, enhancing perceptual sensitivity and sensory representation.

A novel role for TRPV1 in macrophage giant cell formation

This study identifies TRPV1 as a key regulator of macrophage fusion and foreign body giant cell formation, independent of TRPV4.

Effects of Arachis hypogaea extract on TRPV4 activation and epidermal barrier function

This study shows that Arachis hypogaea extract activates TRPV4, increasing intracellular calcium and enhancing epidermal barrier function.

AKAP5 and Caveolin-1 organize opposing nanodomains that regulate smooth muscle contraction and blood pressure

The paper identifies AKAP5 and caveolin-1 as organizers of opposing nanodomains that regulate smooth muscle contraction and blood pressure through distinct signaling pathways.

TRPV4 Promotes Histamine Receptor Signaling in Lymphatic Endothelial Cells

This study shows TRPV4 mediates histamine receptor signaling in lymphatic endothelial cells, enhancing Ca2+ signaling and NFATc1 translocation while cytokine release occurs through distinct mechanisms.

Structural rearrangements underlying the activation of STIM1 by ER calcium depletion

This study investigates how ER calcium depletion triggers structural changes in STIM1 that enable CAD release and Orai1 channel activation through single-molecule FRET experiments.

DHHC21 is a STIM1 protein S-acyltransferase that modulates immune function in vivo

This paper identifies DHHC21 as a STIM1 S-acyltransferase essential for SOCE and immune function, showing its role in ALPS and related diseases.

A novel TRPA1 gain-of-function variant associated with painful sensory neuropathy acts through a PIP2 gating mechanism

This paper identifies a novel TRPA1 variant causing painful sensory neuropathy and shows it functions through a PIP2-dependent mechanism.

Trpv1+ sensory innervation of the salivary gland drives pain and supports saliva secretion

This study identifies Trpv1+ sensory neurons as critical for salivary gland structure and saliva secretion, showing their role in pain and function.