Alcohol Consumption and Health Effects

Evidence for Involvement of WDPCP Gene in Alcohol Consumption, Lipid Metabolism, and Liver Cirrhosis

The paper investigates the role of WDPCP in alcohol consumption, lipid metabolism, and liver cirrhosis using human and model organism studies.

Automated home-cage sipper devices reveal age and sex differences in ethanol consumption patterns

The paper uses automated sipper devices to analyze ethanol consumption patterns in mice, revealing age and sex differences in drinking behavior and circadian rhythms.

The toll-like receptor 7 agonist imiquimod increases ethanol self-administration and induces expression of toll-like receptor related genes

This study shows that TLR7 activation with imiquimod increases ethanol self-administration and induces TLR-related gene expression in rats, with sex-specific effects on drinking behavior and molecular responses.

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

This study uses Mendelian randomization to show that increased alcohol consumption is associated with higher cardiometabolic risks, including elevated blood pressure and mortality, but lower triglycerides and HbA1C.

Genetics and Epigenetics of Aldehyde Dehydrogenase (ALDH2) in Alcohol Related Liver Disease

The paper examines the interaction between genetics and epigenetics at the ALDH2 locus in individuals with and without alcohol-related cirrhosis, finding lower DNA methylation in those with cirrhosis.

Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease

This study shows that alcohol-induced Hsp90 acetylation in liver sinusoidal endothelial cells (LSECs) reduces eNOS interaction and NO production, contributing to alcoholic liver disease, and suggests HDAC6 overexpression as a therapeutic approach.

Cardiovascular Disease Related Proteomic Biomarkers of Alcohol Consumption

This study identifies 20 alcohol-associated proteins and shows complex relationships between alcohol consumption, circulating proteins, and cardiovascular disease risk factors.

Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies

This study performs a functional meta-analysis of transcriptomic studies to identify sex-based differences in biological mechanisms associated with alcohol use disorder.

Phenotyping aldehyde metabolism in humans uncovers novel genetic mutations in aldehyde dehydrogenase 2

The paper develops a method to phenotype ALDH2 genetic differences in humans and identifies novel mutations causing inefficient acetaldehyde metabolism after alcohol consumption.

Multimodal brain imaging study of 36,678 participants reveals adverse effects of moderate drinking

This study finds that moderate alcohol consumption, defined as one to two daily units, is associated with reduced gray matter volume and altered white matter microstructure in middle-aged and older adults.

Critical Variables to be Considered when Attempting to Estimate Blood Ethanol Concentrations in Rats from g/kg Exposure Data

The paper derives estimated blood ethanol concentrations (eBECs) in rats using conversion factors and regression analyses, finding that critical variables like age, sex, dose, and timing vary across datasets.

The Effect of Aldehyde Dehydrogenase Activator, Alda-1(R), on the Ethanol-induced Brain Damage in a Rat of Binge Ethanol Intoxication.

This study examines if Alda-1(R) reduces ethanol-induced brain damage in adolescent rats, finding increased ALDH activity and reduced neuronal damage in the treated group.