Francisco Garcia‐García

This study identifies cholesterol accessibility as a key driver of TLR4-dependent microglial activation, showing that SR-B1 mediates LPS-induced cholesterol uptake and regulates TLR4 signaling and inflammatory responses.

The paper analyzes single-cell data from multiple sclerosis patients to identify sex-specific molecular differences in brain and immune cells across disease progression.

This study identifies consistent sex differences in gut microbiota of MS patients across multiple cohorts, highlighting the importance of sex as a variable in microbiome research.

This study identifies sex-specific miRNA profiles in urinary extracellular vesicles of alcohol use disorder patients, revealing potential biomarkers and mechanistic insights into sex differences in AUD.

The paper analyzes transposable elements in Parkinson Disease datasets to build a cell-type specific atlas and explore their role in sex differences.

MetaOmixTools provides a web-based platform for meta-analysis of ranked features and functional enrichment, enabling integration of multi-study omics data to identify conserved biological insights.

This study characterizes the lipidomic profile of urine extracellular vesicles in male alcohol use disorder patients, identifying FA 22:0 as a potential biomarker linked to inflammation and metabolic dysfunction.

This study integrates miRNomic and lipidomic analysis of plasma extracellular vesicles from AUD patients and controls to identify sex-based molecular signatures and their functional implications.

This study performs a transcriptomic meta-analysis of 44 psoriasis studies to identify immune-related gene expression patterns and novel pathways involved in psoriasis pathogenesis.

This study shows that MCT2 is essential for oligodendrocyte myelin maintenance and axonal support, and its loss leads to myelin and axonal damage, which can be mitigated by a ketogenic diet.

This study identifies sex differences in gene expression, cell-cell communication, and pathway activation in Parkinson's Disease through meta-analysis of single-cell transcriptomic data.

This study investigates the effects of MSC-EVs on neuroinflammation and behavioral impairments caused by chronic alcohol consumption in mice, finding that MSC-EVs reduce inflammation and improve cognitive and addictive-like behaviors.

The paper identifies shared transcriptomic features between melanoma brain metastases and neurodegenerative diseases, highlighting key genes and providing an open-source tool for analysis.

This study identifies sex-specific biomarkers and transcriptomic signatures in subcutaneous adipose tissue for obesity and T2D, highlighting sex differences in molecular mechanisms.

This study investigates how TLR4 and sex affect lipidome changes in EVs from chronically alcohol-exposed mice, identifying lipid subclasses linked to inflammation and EV biogenesis.

MetaFun performs functional meta-analysis of transcriptomic datasets to uncover sex differences across multiple omics studies.

This paper identifies sex-based transcriptomic differences in schizophrenia patients across specific brain regions through meta-analysis of bulk RNA-sequencing studies.

This paper identifies sex-specific genes, transcription factors, and pathways in Alzheimer's disease using meta-analyses of transcriptomic data from the cerebral cortex and hippocampus.

This study shows that mesenchymal stem cell-derived extracellular vesicles reduce hippocampal NLRP3 inflammasome activation and inflammation in adolescent mice after binge ethanol treatment.

This paper identifies sex-specific miRNA expression differences in Alzheimer's disease patients through meta-analysis of blood and brain samples, revealing distinct biological process associations in each sex.

This study identifies severity- and phase-specific biomarker genes for spinal cord injury using transcriptomic analysis and develops a web tool for exploring results.

This study uses lipidomics to analyze plasma extracellular vesicles from AUD patients and healthy individuals, revealing sex-based differences in lipid profiles and their potential links to disease mechanisms.

This study identifies miRNA signatures associated with melanoma progression and prognosis by integrating transcriptomic data and analyzing miRNA-mRNA interactions.

This study identifies sex-based molecular differences in multiple sclerosis through transcriptomic meta-analysis, revealing tissue-specific gene expression patterns and functional immune pathway alterations.

This study identifies sex-based differences in Parkinson's disease transcriptomics through meta-analysis of 267 samples across three brain regions, revealing sex-specific gene expression and pathway alterations.

This paper evaluates sex bias in housekeeping gene expression in adipose tissue using transcriptomics data and identifies sex-unbiased housekeeping genes suitable for use as internal controls.

This paper performs a meta-analysis of transcriptomic studies to identify sex-based differences in molecular mechanisms during the progression from NAFL to NASH.

This study performs a meta-analysis of transcriptomic data to identify sex-based differences in functional signatures of non-small-cell lung cancer, finding enrichment in immune response and purinergic signaling in females.

This study performs a functional meta-analysis of transcriptomic studies to identify sex-based differences in biological mechanisms associated with alcohol use disorder.