Alcohol Consumption and Health Effects

A Biphasic Effect of Alcohol on Endothelial Plasticity Through Regulation of Endothelial-to-Mesenchymal Transition

This study shows alcohol modulates endothelial-to-mesenchymal transition (EndMT) in a biphasic manner, with low-to-moderate doses suppressing and high doses promoting vascular remodeling.

Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

This study identifies HSD11B1 as a direct target of magnesium isoglycyrrhizinate, revealing its therapeutic mechanism in alcohol-associated liver disease through the HSD11B1-SREBP2-IDI1 signaling axis.

Urine proteomic profiling at admission reveals complement biomarkers linked to alcohol-associated liver disease.

The paper identifies complement biomarkers in urine linked to alcohol-associated liver disease and provides insights into liver-kidney crosstalk mechanisms.

Chronic alcohol intake elicits distinct multi-omic profiles in the liver versus skeletal muscle of mice

This study identifies distinct multi-omic profiles in liver and skeletal muscle of mice under chronic alcohol exposure, revealing tissue-specific molecular responses and potential therapeutic targets.

Ablation of sympathetic nerve-β3 adrenergic receptor-mediated adipose tissue lipolysis attenuates alcohol-induced liver injury in mice

Peripheral alcohol metabolism dictates ethanol consumption and drinking microstructure in mice

This study shows that ADH1-mediated ethanol metabolism affects ethanol consumption and drinking patterns in mice, with Adh1 KO and inhibitor treatments reducing consumption and altering drinking microstructure.

A novel mouse home cage lickometer system reveals sex- and housing-based influences on alcohol drinking

This study develops a group-housed lickometer system to investigate how sex and social housing influence ethanol consumption in mice, revealing sex- and housing-based differences in drinking behavior.

Standard rodent diets differentially impact alcohol consumption and preference and gut microbiome diversity

This study shows that different rodent diets affect alcohol consumption and gut microbiome diversity in mice, suggesting diet impacts AUD-related behaviors and gut-brain signaling.

A physiologically-based digital twin for alcohol consumption - predicting real-life drinking responses and long-term plasma PEth

The paper presents a physiologically-based digital twin model that simulates real-life alcohol consumption and connects short-term drinking to long-term PEth levels, enabling personalized predictions and eHealth applications.

Genetic influences on alcohol flushing in East Asian populations

This study identifies genetic variants associated with alcohol flushing in East Asian populations and suggests self-reported flushing can be used as an instrumental variable for alcohol intake.

The toll-like receptor 7 agonist imiquimod increases ethanol self-administration and induces expression of toll-like receptor related genes

This study shows that TLR7 activation with imiquimod increases ethanol self-administration and induces TLR-related gene expression in rats, with sex-specific effects on drinking behavior and molecular responses.

Alcohol use and cardiometabolic risk in the UK Biobank: a Mendelian randomization study

This study uses Mendelian randomization to show that increased alcohol consumption is associated with higher cardiometabolic risks, including elevated blood pressure and mortality, but lower triglycerides and HbA1C.

Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease

This study shows that alcohol-induced Hsp90 acetylation in liver sinusoidal endothelial cells (LSECs) reduces eNOS interaction and NO production, contributing to alcoholic liver disease, and suggests HDAC6 overexpression as a therapeutic approach.

Unveiling sex-based differences in the effects of alcohol abuse: a comprehensive functional meta-analysis of transcriptomic studies

This study performs a functional meta-analysis of transcriptomic studies to identify sex-based differences in biological mechanisms associated with alcohol use disorder.