Molecular BiologyJournal of HepatologyPeer-reviewed
Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease
Yilin Yang, Panjamaporn Sangwung, Reiichiro Kondo…·Yasuko Iwakiri
This study shows that alcohol-induced Hsp90 acetylation in liver sinusoidal endothelial cells (LSECs) reduces eNOS interaction and NO production, contributing to alcoholic liver disease, and suggests HDAC6 overexpression as a therapeutic approach.