Amyloidosis: Diagnosis, Treatment, Outcomes

The paper presents cryo-EM structures of a patient-derived amyloid fibril from systemic AL amyloidosis, revealing structural breaks and a 180-degree rotation around a disulfide bond.

This study shows curcumin increases AApoAII amyloid deposition and liver weight in mice by activating PPARα, affecting lipid metabolism and Apoa2 expression.

This study identifies epigenomic changes in African American Transthyretin Val122Ile carriers linked to heart disease and outpatient surgeries, revealing dysregulated amyloid mechanisms.

This paper introduces LICTOR, a machine learning model that predicts immunoglobulin light chain toxicity in AL using somatic mutations, achieving 83% accuracy in predicting clinical phenotypes.

The paper identifies methylation sites associated with hereditary Transthyretin amyloidosis through an epigenome-wide association study.

The paper investigates the association between the TTR T119M mutation and vascular disease or death in the UK Biobank, finding no significant protective effect.

This study identifies novel associations between TTR and RBP4 gene variants and multiple phenotypes related to hereditary and senile systemic amyloidoses in a large cohort.

AmyCo is a database classifying 74 amyloid-related diseases into amyloidosis and clinical conditions associated with amyloidosis, providing detailed annotations and references to external databases.

The paper evaluates peptide inhibitors in Drosophila models of neuropathic ATTR, finding TabFH2 most effective in improving motor function and reducing TTR deposition.

The paper identifies a novel form of hereditary apoA-I amyloidosis caused by Glu34Lys mutation, revealing structural changes that lead to amyloid formation and vision loss.