Venomous Animal Envenomation and Studies

This study characterizes the diversity and bioactivity of venom metalloproteases in puff adders, identifying distinct forms with varying enzymatic activities and proposing a new nomenclature for the dominant SVMPs.

This study compares venom profiles and activities between melanistic and normally-colored common adders, finding minor differences that are not clinically significant.

This study analyzes venom composition across seven Turkish viper taxa using proteomics and peptidomics, identifying new toxin sequences and comparing them to other Palearctic vipers to improve snakebite risk assessment.

This paper shows that melatonin receptor agonists promote functional recovery from krait venom-induced neuroparalysis in mice, suggesting their potential use in human snakebite treatment.

The paper assembles and annotates the genome of Echis carinatus, identifying toxin-coding genes and providing a resource for venom research.

The paper presents a high-quality genome assembly and transcriptomic data for the striped scorpion, Centruroides vittatus, identifying venom toxin genes and expression differences between venom gland and body tissue.

The paper designs peptides targeting nAChR using molecular docking and dynamics to develop therapeutic options for Dyskinesia, showing a novel peptide has better binding affinity than a full toxin.

The paper reconstructs the evolutionary history of three-finger toxins (3FTxs) and identifies their non-toxin ancestor as a non-secretory Ly6 in squamate reptiles.

ALOHA is an AI-guided tool that quantifies venom-induced haemorrhage in mice using smartphone imaging, reducing analysis time and human error.

This paper validates a colorimetric LAMP assay for detecting Loxosceles envenomation, showing high sensitivity and specificity compared to PCR.

The paper investigates the role of an aromatic cage in the lipid specificity of Loxosceles α clade phospholipase D enzymes using molecular dynamics simulations and experimental validation.

ScrepYard is an online resource for identifying and characterizing SCREP sequences, revealing structural features of multivalent peptides and demonstrating its utility in virtual screening.

A recombinant human monoclonal antibody was optimized to neutralize whole cobra venom in mice, preventing lethality by targeting neurotoxins.

The paper characterizes the skin transcriptomic profiles of Oophaga poison frogs to understand the genetic basis of their aposematic traits and chemical defenses.

The paper reports the genome sequence of the wandering spider Pardosa pseudoannulata and analyzes genes related to silk and venom toxin production, revealing insights into its neurotoxin selectivity and potential pest control role.

The paper analyzes transcriptomic and genomic data from Conus consors to identify protein sequences and conopeptides.

VenomKB v2.0 is an open-access resource for venom bioactivities, sequences, and classifications, providing tools for computational toxinology and drug discovery.

The paper compares toxin-associated gene homologs in Daboia russelii using whole-genome sequencing data from skin exuviate, identifying unique sequence motifs and structural residues across venom domains.