Cholangiocarcinoma and Gallbladder Cancer Studies

This study uses spatial transcriptomics to analyze two gallbladder cancer patients, showing distinct progression paths and the role of SEMA4A repression in tumor development.

This study identifies two proteomic subgroups of intrahepatic cholangiocarcinoma with distinct time-to-recurrence rates and biological processes.

This study identifies CCA subtype-specific biomarkers through bioinformatics analysis of transcriptomic data and machine learning prediction of transcription factors.

This study uses bioinformatics to identify shared differentially expressed genes between SARS-CoV-2 infection and intrahepatic cholangiocarcinoma, revealing potential therapeutic targets.

This study traces the evolutionary paths of gallbladder adenocarcinomas, showing subclonal diversification and selection from precancerous lesions to metastatic tumors.

This study identifies key genes and transcription factors linked to gallbladder cancer pathogenesis using integrative systems biology approaches and transcriptomic data analysis.

The paper shows that CagA+ Helicobacter pylori infection induces epithelial to mesenchymal transition in human cholangiocytes, promoting migration, invasion, and colony formation.

The paper investigates how liver fluke granulin promotes exosome-mediated crosstalk that alters the cellular microenvironment to support cholangiocarcinoma development.

The paper identifies ATG7 as a genetic risk factor for cholangiocarcinoma through germline mutations and population studies, linking autophagy dysfunction to cancer development.