Long-Term Effects of COVID-19

Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome

This study identifies structural brain deviations in post-COVID-19 patients using normative modelling and network analysis, linking them to TMPRSS2 expression and neural circuit disruptions.

Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice

The paper investigates whether IgG from long COVID patients with neurological symptoms can induce pain-related symptoms in mice, finding that they bind to sensory neurons and cause transient mechanical allodynia.

TACO: TabPFN Augmented Causal Outcomes for Early Detection of Long COVID

TACO detects presymptomatic Long COVID by combining causal inference with a foundation model, achieving higher precision with fewer features and no hyperparameter tuning.

Transfer of IgG from Long COVID patients induces symptomology in mice

This study transfers IgG from Long COVID patients to mice, inducing distinct symptoms based on patient subgroups, supporting a causative role for IgGs in Long COVID.

Pediatric Long COVID Is Characterized by Myeloid CCR6 Suppression and Immune Dysregulation

This study identifies immune dysregulation and myeloid CCR6 suppression in pediatric long COVID, with CCR6 expression distinguishing long COVID from controls.

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome

This study uses multimodal MRI to find altered brain perfusion and oxygen metabolism in PCS, linked to cognitive and emotional symptoms.

EEG Signatures of COVID-19 Survival compared to close contacts and the Cuban EEG normative database

The paper compares EEG patterns between COVID-19 survivors, close contacts, and a normative database to identify brain function impairments and abnormal activity patterns.

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry

This study identifies a genetic association between thromboembolism risk and long COVID in individuals of European ancestry, suggesting thromboembolism as a potential contributor to long COVID pathogenesis.

Omics-Based Computational Approaches for Biomarker Identification, Prediction, and Treatment of Long COVID

This paper reviews computational methods and datasets for understanding Long COVID's mechanisms and developing diagnostic and therapeutic strategies using multi-omics data.

Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID

This paper identifies 32 causal genes for Long COVID using a multi-omics framework combining TWMR and CT, revealing novel genetic factors and symptom subtypes.

Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates

This study investigates how obesity affects the long-term effects of SARS-CoV-2 infection in nonhuman primates, finding persistent changes in multiple parameters in most animals.

Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem

This study shows that SARS-CoV-2 infects and persists in hamster brainstem, causing neurodegenerative and immunometabolic changes linked to neuropsychiatric and cognitive symptoms.

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

This study identifies elevated oxidative stress in both ME/CFS and Long COVID patients through blood cell analysis, suggesting shared molecular mechanisms and potential therapeutic targets.

Immunological and clinical markers of post-acute sequelae of COVID-19: Insights from mild and severe cases six months post-infection

This study identifies immunological markers associated with PASC in patients six months post-COVID-19 infection, showing altered T-cell subsets and cytokine profiles linked to disease severity and symptom duration.

Genome-wide Association Study of Long COVID

This study performs a genome-wide association study for Long COVID, identifying a significant association with the FOXP4 locus and highlighting the role of pulmonary dysfunction and COVID-19 severity.

LEF1-AS1 deregulation in the peripheral blood of patients with persistent post-COVID symptoms

This study investigates ncRNA expression in long COVID patients and finds LEF1-AS1 downregulation in PBMCs of symptomatic individuals.

Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID

Mobius, a transformer model using DNA methylation data, accurately distinguishes ME/CFS, Long COVID, and healthy controls with high performance.

Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries

This study reproduces genetic risk factors for long COVID identified in a European ancestry cohort across ancestrally diverse populations, showing significant enrichment of disease signatures and supporting drug repurposing candidates.

Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets

This study investigates SARS-CoV-2 neuroinvasive and neurovirulent potential in ferrets with mild respiratory disease, finding limited neuroinvasion but evidence of neurovirulence through microglial and astrocytic changes.

Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice

This study establishes a sex-dependent mouse model of post-COVID syndrome, showing neuropsychiatric and musculoskeletal complications in females that are prevented by ovariectomy.

Sex differences and immune correlates of Long COVID development, persistence, and resolution

This study identifies sex-specific immune correlates of Long COVID development, persistence, and resolution using multi-omic analyses of blood samples from patients with and without Long COVID.

Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice

This study investigates SARS-CoV-2 neuroinvasion via the trigeminal nerve in AC70 human ACE2 transgenic mice, finding it as an efficient route with altered neuronal function and gene expression but limited tissue pathology.

Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs

This study shows that olcegepant reduces weight loss and IL-6 release in older mice infected with SARS-CoV-2, suggesting potential neuroprotective effects against coronavirus-induced inflammation.

Neuroinflammation in post-acute sequelae of COVID-19 (PASC) as assessed by PBR28 PET correlates with vascular disease measures

This study finds that neuroinflammation, measured by PBR28 PET, is increased in PASC patients and correlates with vascular dysfunction markers in blood.

Associations between COVID-19 and putative markers of neuroinflammation: A diffusion basis spectrum imaging study.

This study investigates associations between COVID-19 and neuroinflammation markers using DBSI in UK Biobank data, finding increased vasogenic edema in specific brain regions.

SARS-CoV-2 RNA Persists in the Central Nervous System of Non-Human Primates Despite Clinical Recovery

This study shows SARS-CoV-2 RNA persists in the CNS of recovered non-human primates, with ACE2 and TMPRSS2 downregulation and pericyte infection linked to PASC.

Genetic Risk Factors for Severe and Fatigue Dominant Long COVID and Commonalities with ME/CFS Identified by Combinatorial Analysis

This paper identifies 73 genes associated with severe or fatigue dominant long COVID through combinatorial analysis and finds overlaps with ME/CFS and potential drug targets.

The hypothalamus as a hub for SARS-CoV-2 brain infection and pathogenesis

The paper investigates SARS-CoV-2 infection in the hypothalamus and associated regions, showing viral entry receptors and susceptibility factors linked to neurological symptoms in COVID-19.

Long COVID: G Protein-Coupled Receptors (GPCRs) responsible for persistent post-COVID symptoms

This paper identifies GPCRs and related genes associated with long COVID symptoms using computational analysis of gene expression and drug interactions.

Molecular and cellular similarities in the brain of SARS-CoV-2 and Alzheimer's disease individuals

This study compares transcriptional and cellular changes in brain regions of SARS-CoV-2 infected, Alzheimer's disease, and SARS-CoV-2 infected Alzheimer's disease individuals to identify shared neuroinflammatory and blood-brain barrier alterations.