Author

Aleksandra K. Drelich

The University of Texas Medical Branch at GalvestonORCID 0000-0002-0201-5017Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Genomics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Chien-Te Kent TsengiD· 4 shared Bi‐Hung PengiD· 3 shared Panatda SaenkhamiD· 3 shared Barbara M. JudyiD· 2 shared Jason C. HsuiD· 2 shared Thomas G. KsiazekiD· 2 shared Bin CheniD· 1 shared Cássio Pontes Octaviani· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

Chien-Te Kent TsengORCID

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Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintApr 3, 2025

Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2

Aleksandra K. Drelich, Panatda Saenkham, Yu-Hsiu Wang…·Chien-Te Kent Tseng

This study investigates prolonged neurological effects in AC70 hACE2 Tg mice infected with Omicron BA.1, showing BBB disruption, neuroinflammation, and coagulopathy contribute to long-COVID-like symptoms.

DOI 10.1101/2025.04.03.646981

mouseexperimental assay

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PathologyFrontiers in MicrobiologyPeer-reviewedSep 24, 2024

Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice

Jason C. Hsu, Panatda Saenkham, Pinghan Huang…·Chien-Te Kent Tseng

This study investigates SARS-CoV-2 neuroinvasion via the trigeminal nerve in AC70 human ACE2 transgenic mice, finding it as an efficient route with altered neuronal function and gene expression but limited tissue pathology.

10 citations

mouseexperimental assay

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MicrobiologyPLoS PathogensPeer-reviewedJun 24, 2024

Characterization of Unique Pathological Features of COVID-Associated Coagulopathy: Studies with AC70 hACE2 Transgenic Mice Highly Permissive to SARS-CoV-2 Infection

Aleksandra K. Drelich, Kempaiah Rayavara, Jason C. Hsu…·Chien-Te Kent Tseng

This study characterizes the coagulopathy in AC70 hACE2 transgenic mice infected with SARS-CoV-2, revealing hypercoagulable states and ANXA2 system dysregulation.

10 citations

mouseexperimental assay

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GenomicsbioRxivPreprintApr 7, 2020

Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19

Jing Xing, Rama Shankar, Aleksandra K. Drelich…·Bin Chen

37 citations

humanbulk RNA-seq

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