Jay Rappaport

This study shows HIV reduces T follicular helper cells and alters germinal center structure in people living with HIV, independent of CD4 count.

This study shows that long-term ART in SIV-infected macaques reduces acute inflammation but maintains chronic macrophage and TLR-driven inflammation linked to vascular damage and aging.

This study links elevated IL-1β and IL-18 levels with gut barrier disruption and monocyte activation in SIV-infected macaques on long-term ART, suggesting a role in CVD and metabolic complications.

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

This study shows SARS-CoV-2 RNA persists in the CNS of recovered non-human primates, with ACE2 and TMPRSS2 downregulation and pericyte infection linked to PASC.