Cerebrospinal fluid and hydrocephalus

The paper investigates how autonomic regulation of cerebral vascular tone generates CSF pulsations during sleep and may aid in brain waste clearance.

This study investigates the effect of nasal inhalation of prostaglandin F2alpha analogs on cerebrospinal fluid (CSF) outflow via nasal lymphatics in mice, finding increased tracer recovery with latanoprost.

The paper compares brain lymphatic endothelial cells (BLECs) to scavenging endothelial cells (SECs) in the zebrafish and identifies Mrc1a as a key receptor for cargo uptake in BLECs.

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

This study finds that reduced coupling between global brain activity and cerebrospinal fluid flow is associated with cognitive impairment in Parkinson's patients.

The paper demonstrates that bulk CSF flow in periarterial spaces is not an artifact of injection, using a dual-syringe system that prevents volume changes and pressure increases.

The paper investigates glymphatic function in a large mammal with a highly gyrified brain, showing CSF penetration and enhanced solute transport compared to mice.

The paper identifies potassium-driven cerebrospinal fluid (CSF) clearance through the choroid plexus during a critical neurodevelopmental phase in mice, showing its role in preventing hydrocephalus.

The paper analyzes cerebral perivascular spaces (PVS) in healthy individuals to establish normal ranges and identifies factors like BMI, time of day, and genetics that influence PVS volume and distribution.

The paper characterizes astrocyte endfoot dimensions along the vascular tree in mice and shows that varying endfoot sizes maintain perivascular-interstitial fluid flux despite pressure changes.

This study shows that focused ultrasound with microbubbles improves beta-amyloid drainage in Alzheimer's model mice by enhancing brain-to-cerebrospinal fluid clearance.

This study shows that functional hyperemia drives fluid exchange in the paravascular space by interacting with brain tissue deformability.

This study shows that increasing convective forces after intrathecal injection improves rostral distribution of therapeutic ASOs in the CNS of cynomolgus monkeys.

This study uses fluid dynamic simulations to show that arterial pulsations cause oscillatory CSF motion, not directional pumping, and that directional flow results from pressure differences.

The paper quantifies uncertainty in tracer distribution in the brain by simulating diffusion and convection models and comparing results to experimental MRI data.

The paper shows that the observed shapes of perivascular spaces (PVSs) in the brain have lower hydraulic resistance than concentric, circular annuli, allowing faster cerebrospinal fluid flow.

This study investigates the anatomical and physiological role of cerebrospinal fluid transport through the murine cribriform plate and finds that olfactory sensory nerves are critical for CSF outflow.

This study uses dynamic 11C-PiB PET to show reduced cerebrospinal fluid clearance in Alzheimer’s disease and multiple sclerosis compared to healthy controls.

The paper compares two mathematical models of cerebrospinal fluid dynamics using numerical simulations and validates them against real data from literature.

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.

The paper investigates the applicability of Davson’s equation in idiopathic normal pressure hydrocephalus patients, finding a weak but significant correlation between intracranial pressure and outflow resistance.