Biochemical Analysis and Sensing Techniques

This study uses calcium imaging to show that taste representations in the gustatory insular cortex of awake mice are sparse and distributed, lacking spatial clustering or topography.

The paper identifies a new subset of Type III taste cells that respond to multiple taste stimuli and uses genetic and imaging approaches to characterize their signaling pathways.

The paper investigates genetic factors influencing dietary fat perception using twin studies and GWAS, finding genetic variants associated with potato chip liking.

This study models the human tongue as a porous medium to understand taste perception timing, finding that molecular size affects the delay and intensity of taste perception.

This study investigates how the gustatory cortex of mice encodes chemosensory and hedonic features of taste during active licking, showing rapid encoding of taste identity and licking-related activity.

This study investigates whether diet or weight gain causes taste deficits in diet-induced obese mice, finding that both factors contribute to reduced taste responses.

This study uses high-resolution fMRI to show that taste quality is represented by a combinatorial spatial code rather than a topographic map in the human brain.

The paper uses serial blockface scanning electron microscopy to describe the morphology and distribution of cell types in mouse circumvallate taste buds.

The paper records spiking activity in mouse gustatory cortex during taste stimulation, finding temporal coding of taste identity and palatability and no anatomical taste specialization.

This study uses molecular dynamics simulations to investigate how different umami ligands affect the structural dynamics of the T1R1-T1R3 taste receptor, identifying key residues and binding sites involved in ligand recognition.

The paper investigates how bitter taste and nociceptive stimuli are linked in mouse parabrachial nucleus neurons using electrophysiology and optogenetics.

The paper investigates responses of mouse trigeminal ganglion neurons to kokumi substances using in vivo confocal Ca2+ imaging, finding that these substances evoke responses in a small fraction of neurons.

The paper investigates how sucrose intensity is encoded and used for decision-making in rat gustatory cortices, finding that a few intensity-selective neurons convey most of the information.

The paper investigates whether TAS2R38 mRNA expression in taste tissue correlates with expression in sinonasal tissue among heterozygotes, finding no significant relationship.

The paper measures bitter taste receptor mRNA expression in human skin and finds individual variation linked to sun exposure, sex, and age.

This study performs a bivariate GWAS to identify new common variants influencing bitter taste perception, finding small-effect SNPs on chromosomes 7 and 12.

The paper examines how TAS2R38 genetic variants affecting bitter taste perception influence vegetable intake in response to different dietary interventions.

The paper identifies IR56d-expressing neurons as necessary and sufficient for fatty acid taste in Drosophila, showing they mediate feeding responses and distinguish FA from sugar.

The paper uses two-photon imaging to show that a specific gustatory cortex region contains overlapping representations of primary tastes and encodes both taste quality and hedonics.