Cholesterol and Lipid Metabolism

The paper uses genome-scale CRISPR screening to identify genetic modifiers of LDL uptake in hepatocytes, finding several new genes involved in this process.

This paper identifies a proteasomally truncated form of the cholesterol synthesis enzyme SM that is constitutively active and resistant to cholesterol-induced degradation.

This study identifies GOLIATH as an E3 ubiquitin ligase that regulates LDLR availability and plasma LDL cholesterol levels by ubiquitinating LDLR and redistributing it away from the plasma membrane.

The paper identifies rs1997243 as a risk variant for hypercholesterolemia that increases GPR146 expression, showing its role in regulating blood cholesterol in human and mouse models.

This study identifies miR-27a as a regulator of Hmgcr and cholesterol biosynthesis, showing its role in modulating plasma cholesterol levels in mice.

The paper identifies promoter polymorphisms in the Hmgcr gene that reduce its expression in rat hypertension models by altering transcription factor binding.

The paper introduces LipoGlo, a system using ApoB-fused luciferase to monitor lipoprotein atherogenicity in zebrafish, revealing new localization patterns and identifying a regulator of lipoprotein size.

The paper identifies genetic regulation of HDL proteome variation across mouse strains, revealing coordinated protein regulation and functional diversity in HDL subspecies.

The paper develops an agent-based model of lipoprotein metabolism to investigate how high plasma triglycerides lead to low HDL cholesterol, finding that excess surface lipids from VLDL are cleared independently of HDL.

This study shows that phosphorylation of LXRα affects atherosclerosis regression by altering macrophage trafficking in diabetic mice.