Prenatal Substance Exposure Effects

This study shows that prenatal cannabis smoke exposure in mice reduces placental size and function and affects fetal brain growth.

This study shows that endothelial NMDA receptors are critical for retinal vascular development and mediate prenatal alcohol exposure-induced neurovascular defects in mice.

This study identifies ACSS2 as a mediator of prenatal alcohol exposure-related phenotypes, showing its role in histone acetylation and developmental changes in the brain.

This study examines sex-specific and time-dependent behavioral and metabolomic changes in mice after adolescent binge ethanol exposure.

This study shows alcohol disrupts neural differentiation by inducing ER stress and PERK pathway activation in both in vitro and in vivo models of prenatal alcohol exposure.

This study shows that e-cigarette aerosol exposure during pregnancy reduces GABA neuron migration via α7 nAChR activation, highlighting risks for neurodevelopment.

This study investigates how ethanol affects facial development in zebrafish by examining interactions between the BMP and PCP pathways during specific developmental time windows.

This study shows that prenatal alcohol exposure disrupts circadian rhythms and gene expression in mice, affecting behavior and memory.

This study examines the effects of prenatal THC exposure on mouse brain development using MRI across the lifespan, finding sex-dependent neurodevelopmental impacts.

This study shows that perinatal fluoxetine exposure increases sexual behavior in adult male rats, suggesting long-term effects of serotonin on sexual function.

This study shows that prenatal alcohol exposure reduces cholinergic interneurons and their activity in the striatum, leading to impaired cognitive flexibility and compulsive drinking behaviors in adult offspring.

This study examines the effects of prenatal alcohol and synthetic cannabinoid co-exposure on mouse offspring survival, physical development, and neurobehavioral outcomes, finding increased mortality and sex-specific behavioral impairments.

The paper shows a single binge ethanol exposure rapidly increases apoptosis in early adolescent and adult mice, with Myt1l haploinsufficiency modulating this effect across developmental stages.

This study shows that perinatal fentanyl exposure in rats leads to long-term addiction risk and central amygdala gene dysregulation, providing insights into the molecular mechanisms of NOWS and its consequences.

This study shows that prenatal THC exposure and maternal stress impair maternal behavior and alter offspring neurodevelopment with sex- and region-specific molecular changes.

This study shows that sodium butyrate reduces neurodevelopmental deficits in rats exposed to methadone prenatally by improving gut-brain axis function and myelination.

This study examines ultrasonic vocalizations (USVs) in FVB/N mouse pups during neonatal opioid withdrawal, identifying syllable sequences and acoustic properties linked to withdrawal severity.

The paper uses in vivo electrophysiology and dimensionality reduction to show alcohol exposure reduces firing rates in thalamic neurons but increases hippocampal excitability in mice.

This study examines the effects of perinatal morphine exposure on maternal behavior and offspring anhedonia in rats, finding disrupted maternal behavior and reduced sucrose preference in offspring.

This study examines how alcohol exposure affects the transcriptome, methylome, and metabolome of human embryonic cells during gastrulation, identifying key gene and metabolic changes linked to fetal alcohol spectrum disorders.

This study shows ethanol disrupts gastrula gene expression and cell movement in zebrafish, leading to developmental defects similar to human FASDs.

This study shows that prenatal cannabinoid exposure impairs respiratory and autonomic control in juvenile rats, with sex-specific effects on reflex responses to hypoxia and hypercapnia.

This study examines USV profiles and kappa opioid receptor involvement in neonatal opioid withdrawal in female mice, finding increased Complex 3 syllables and female-specific KOR system activation.

This study examines sex-specific DNA methylation and gene expression changes in mouse placentas after early preimplantation alcohol exposure, finding significant differences in molecular profiles between male and female placentas.

This study examines how prenatal tobacco and alcohol exposure affects cortical structure and development in early adolescence using longitudinal data from the ABCD Study.

This study investigates how prenatal alcohol exposure (PAE) affects GABAergic transmission and acute alcohol's effects in the CeM of adolescent rats, revealing sex-specific changes in synaptic activity.

This study shows that third trimester alcohol exposure in rats disrupts prefrontal-hippocampal oscillatory interactions and choice behaviors during a working memory task.

This study shows alcohol induces p53-mediated apoptosis in neural crest cells by activating AMPK, which suppresses TORC1, p70/S6K, and ribosomal biogenesis.