Prenatal Substance Exposure Effects

This study shows that gestational ethanol exposure in mice causes sex-specific striatal deficits in acetylcholine and dopamine function, linked to impaired motor learning and altered receptor modulation.

This study compares long-term effects of in utero versus continued postnatal oxycodone exposure in mice, finding sex-dependent changes in sensory and reward processing but no major behavioral deficits.

This study examines the effects of prenatal drug exposure on synaptogenesis in the mesolimbic dopamine pathway in mice, finding increased excitatory and decreased inhibitory synapses in specific brain regions.

This study investigates sex differences in behavioral and brainstem transcriptomic changes in mice exposed to neonatal opioids, finding sex-specific neuroadaptations linked to NOWS-like behaviors.

This study shows that pre-implantation alcohol exposure causes sex-specific DNA methylation errors in fetal mouse forebrains, potentially contributing to FASD-related neurodevelopmental issues.

This study shows that environmental enrichment can reverse behavioral and synaptic deficits caused by perinatal fentanyl exposure in mice.

This study examines the effects of developmental alcohol exposure on adult Drosophila phenotypes and brain gene expression, revealing sexual dimorphism and similarities to cocaine-induced gene expression changes.

This study shows that cannabidiol treatment during peri-adolescence improves cognitive deficits and reduces neuroinflammation in a mouse model of fetal alcohol spectrum disorder.

This study identifies white matter microstructural differences in young children with prenatal alcohol exposure compared to controls using diffusion tensor imaging.

This study examines the effects of prenatal methadone exposure on mouse offspring, finding impairments in physical growth, sensorimotor behavior, and motor neuron function.

This study identifies transcriptomic changes in cortical neurons exposed to early chronic ethanol, highlighting altered pathways and a caudal molecular shift associated with FASD.

The paper investigates the effects of moderate prenatal ethanol exposure on axon development in E15.5 mice, finding increased L1+ axon length.

This study examines the effects of in utero and postnatal oxycodone exposure on mouse behavior and development, finding sex-dependent weight changes, altered vocalizations, and sensorimotor delays.

This study shows that prenatal THC exposure does not alter mesolimbic dopamine function or behavior in female rats, unlike males.

This study shows that perinatal fentanyl exposure causes long-term impairments in somatosensory function and behavior in mice, with changes in synaptic and morphological properties.

This study examines the effects of neonatal ethanol exposure on GABAergic neurotransmission in the retrosplenial cortex of adolescent mice, finding altered parvalbumin interneuron function.

This study shows that prenatal cannabis vapor exposure in rats leads to long-term behavioral changes in offspring, including altered emotional reactivity, social behavior, and cognitive flexibility.

A deep neural network identifies novel behavioral effects of maternal nicotine exposure on rat pups, revealing altered motor development and movement patterns.

The paper investigates gene-environment interactions in zebrafish embryos, showing ethanol interacts with vangl2 and Shh pathways to cause midfacial defects.

This study shows that prenatal ethanol exposure affects social anxiety and ethanol intake differently in male and female offspring, with high social anxiety linked to increased ethanol consumption.

The paper investigates hippocampal gene expression changes in a mouse model of FASD following prenatal alcohol exposure and maternal separation, identifying altered RNA processing as a potential mechanism for anxiety-like behavior.

This study shows that perinatal fentanyl exposure in mice leads to somatic withdrawal and lifelong neurobehavioral changes similar to human neonatal opioid withdrawal syndrome.

This study finds that moderate episodic prenatal alcohol exposure in rats does not significantly affect female offspring fertility parameters.

The paper identifies the indusium griseum as a prenatal target of psychostimulants and shows that Scgn+/Vglut1+ neurons in this region are critical for neuronal excitability and linked to behavioral abnormalities.

This study shows that prenatal alcohol exposure disrupts the Shh pathway and primary cilia in mouse neural tube, suggesting a transient ciliopathy as a mechanism for alcohol-related birth defects.

This study examines the effects of acute prenatal alcohol exposure on glucose metabolism and insulin resistance in male rat offspring, finding sex-specific metabolic dysfunction.

This study shows that bumetanide, an NKCC1 antagonist, prevents ethanol-induced interneuronopathy and behavioral deficits in a FASD model.

This study examines the behavioral effects of prenatal exposure to ethanol and cannabis in rats, finding additive negative impacts on activity and spatial learning.

This study finds that perinatal exposure to maternal smoking is associated with reduced cortical surface area in specific brain regions and increased disease risk in middle-aged and older adults.