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This study shows that G proteins and β-arrestins can directly interact, with Gi family members differing in their association with β-arrestin, and this selectivity is located in the alpha helical domain of Gi.

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

This study defines DNAJA2 co-chaperone client selectivity using pulse-SILAC and BioID to reveal distinct protein pools associated with DNAJA2 based on structural and physicochemical properties.

This paper uses absolute quantitative proteomics to identify patient-specific drug repurposing strategies for clear cell and papillary renal cell carcinoma.

The paper identifies a new family of dehydrating condensation domain proteins involved in the biosynthesis of azabicyclocarbamates in Pseudomonas aeruginosa.

This paper identifies separate metal-binding sites in Pol γ that regulate its DNA synthesis and strand displacement activities, revealing structural and biochemical mechanisms for mitochondrial DNA replication.

The paper investigates ZnF-UBP domains in USP DUBs, showing they relieve product inhibition by facilitating Ub release, thereby regulating enzyme activity.

This paper compares experimental and computational studies of EgtB and ACCO to understand how their coordination sphere affects anion rebound selectivity in nonheme Fe enzyme-catalyzed C(sp3)-H functionalization.

This study identifies VDAC2 as a regulator of BAX activation by stabilizing a primed, membrane-inserted intermediate in the BAX activation pathway.

This study investigates how ETS-family transcription factors bind to UV-damaged DNA and inhibit repair, revealing structural and dynamic differences that explain mutation hotspots in melanoma.

This study investigates how Tau and Fyn interact to regulate postsynaptic density condensate dynamics, showing that their multivalent interactions cooperatively arrest condensate components.

The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.

This paper develops two new trehalose-based fluorophores for detecting live mycobacteria, showing improved spectral range and drug susceptibility reporting.

This study identifies the keto form of oxaloacetate as the substrate for Vibrio cholerae decarboxylase and elucidates the proton transport mechanism during catalysis.

This study presents cryo-EM structures of human ASIC1a across different pH levels and conditions, revealing conformational changes linked to channel function.

This study investigates the direct interactions of CEACAM1 and CD36 with micellar LPS and each other, revealing cooperative binding and implications for innate immunity and lipid metabolism.

This study identifies substrate biasing in UCHL5 proteoforms, showing N-terminal ubiquitination activates the enzyme toward monoubiquitin substrates and regulates debranching activity.

This study shows how promoter architecture in Pseudomonas aeruginosa determines different transcriptional outputs from the same ParR phosphorylation signal.

This study reconstitutes Ras-PI3Kγ membrane communication and feedback using light-induced signaling inputs, revealing how feedback and diffusion shape spatiotemporal signaling dynamics.