Qingyue Zhang

This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.

The paper integrates multiple affinity purification strategies to uncover novel protein interactions, validating the FOXA1-PBX1 complex as a regulatory node in estrogen receptor transcription.

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.

This study shows D-type cyclins inhibit mismatch repair (MMR) in G1 phase by shielding p21, while their degradation in S phase enables proper MMR function, maintaining genome stability.