Discover, rate, and verify biology preprints.

Scalable high-density tactile arenas for measuring ground-contact forces in freely moving animals

This paper introduces a scalable tactile sensing platform to measure ground-contact forces in freely moving animals, detecting changes in limb loading after sciatic nerve injury.

A Real-Time Automated Deep Learning Workflow for Non-invasive High-Magnification Imaging of C. elegans

This paper develops a real-time deep learning workflow for non-invasive high-magnification imaging of C. elegans, enabling stable imaging across magnifications without immobilization.

A Personalized Approach to Student Mental Health: Real-Time EEG Biofeedback for Stress and Focus Management

This paper explores a personalized EEG biofeedback approach for stress and focus management using subject-specific thresholds and a two-channel EEG setup.

An open-source, 3D-printable droplet microfluidics platform with strobe-enhanced microscopy

This paper introduces an open-source, 3D-printable droplet microfluidics platform with stroboscopic microscopy for stable droplet generation and low-flow control.

Nanotherapy-mediated biased antigen-presenting cell reprogramming supports T cell anergy to prevent type 1 diabetes

This paper develops a nanotherapy to reprogram antigen-presenting cells and induce T cell anergy, delaying type 1 diabetes onset in mice.

Interpretable computational SHG microscopy enables quantitative tissue phenotyping of cardiac remodeling in nonischemic heart failure

The paper develops an interpretable computational SHG microscopy framework to classify cardiac remodeling states in mice with high accuracy.

Increased EV yield and bioactivity of matrix-bound nanovesicles compared to conditioned culture medium-derived extracellular vesicles

This study compares EV yields and bioactivity between liquid-EVs and MBVs from MSCs, finding MBVs have significantly higher yields and are more effective in wound repair.

Multi-Angle Lateral-View Breast Tissue Classification in Thermographic Images Using Deep Reinforcement Learning and Statistical Shape Modelling

This paper develops a hybrid method combining deep reinforcement learning and statistical shape modeling to improve breast tissue classification in thermographic images, achieving 74.1% accuracy.

Mesaconate-Based Polyester Nanoparticles Reveal How Metabolite Isomerism Shapes Polymer Behavior, Macrophage Reprogramming, and Systemic Immunomodulation

This study creates mesaconate-based polyester nanoparticles that show different immunomodulatory effects in macrophages and improve survival in endotoxemia.

Substrate chemistry in cancer bioelectronics: phenotype-dependent cell-electrode coupling and motility

This study examines how electrode coatings affect cell-electrode coupling and motility in different breast epithelial phenotypes, finding that coating effects vary with cell type.

Collagen V Presented at the Cell-Substrate Interface Mimics Substrate Stiffening to Enhance Fibroblast Traction, Adhesion Turnover, and Persistent Migration

This study shows that presenting collagen V at a cell-substrate interface enhances fibroblast traction, adhesion turnover, and migration, mimicking the effects of substrate stiffening.

Novel 3D Mature Osteocyte Perfusion Platform Reveals Subtype-Dependent and Radiation-Sensitive Disruption of Mechanotransduction by Breast Cancer Secretomes

This study shows that breast cancer subtype and radiation affect osteocyte mechanosensing, with ER+ tumors being more sensitive to radiation-induced secretome changes.

Spheroid surgery: a first-generation micromanipulation platform for extracting viable cell clusters from the outer layers of hydrogel-embedded spheroids

This paper introduces a micromanipulation platform to extract viable cell clusters from hydrogel-embedded 3D spheroids without disrupting the parent structure.

Multiviral RBD-decorated chimpanzee adenoviral vaccine elicits broad neutralizing immunity against diverse betacoronaviruses

Cellular Traction and Morphological Adaptation to Cell-Scale Stiffness Gradients on Length-Encoded Micropillar Arrays

This paper develops a micropillar array platform to study how cancer cells respond to mechanical stiffness gradients at the cell scale, finding biphasic pillar displacement and increased traction forces with stiffness.

Recombinant spore-displayed enzymes for cellulose hydrolysis: dual-enzyme spores versus mixed single-enzyme spores

This study compares dual-enzyme spore display with mixed single-enzyme spores for cellulose hydrolysis, finding that mixing single-enzyme spores yields higher glucose production.

Do protein representations encode variant function? Diagnosing residue-level protein attributions via embedding-space gradients

This paper evaluates residue-level attributions in protein language models using synthetic fitness landscapes and identifies interventions that improve attribution accuracy.

kinGEMs: A Robust and Scalable Framework for Resource-Constraint Models through Stochastic Tuning of Deep Learning-Predicted Kinetic Parameters

This paper introduces kinGEMs, a framework that integrates deep learning-predicted kinetic parameters into genome-scale models to improve metabolic modeling accuracy and scalability.

Anatomically Programmable and Optically Tunable 3D-Bioprinted Tumor-Mimicking Phantoms for Quantitative Nanofluorophore Benchmarking

This paper develops 3D-bioprinted tumor-mimicking phantoms to benchmark nanofluorophores under surgical conditions, showing their ability to evaluate fluorescence properties and guide tumor resection.

Recombinant surface display of lichenase on Bacillus subtilis spores to improve animal feed digestibility

This study displays a lichenase on Bacillus subtilis spores, enhancing its thermal stability and feed substrate hydrolysis efficiency compared to the free enzyme.