Multiviral RBD-decorated chimpanzee adenoviral vaccine elicits broad neutralizing immunity against diverse betacoronaviruses
Bethany G. Charlton, Rosa D'Agostino, Rebecca A Russell…·Matthew D. J. Dicks
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University of OxfordORCID 0000-0002-6517-6483Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Bethany G. Charlton, Rosa D'Agostino, Rebecca A Russell…·Matthew D. J. Dicks
Zhenyu Li, Matthew D. J. Dicks, Louisa M. Rose…·Dan H. Barouch
This study shows that displaying an antigen on adenovirus capsids and encoding it as a transgene enhances both humoral and cellular immune responses in rhesus macaques.
Rebecca A Russell, James B. Lok, James Michael Harris…·Matthew D. J. Dicks
This study develops a vaccine using PreS1-decorated adenovirus that induces neutralizing antibodies and T-cell responses against HBV and HDV.
Gregory M. Martin, Rebecca A Russell, Philipp Mundsperger…·Quentin James Sattentau
This study shows that chemical cross-linking with EDC stabilizes HIV-1 Env trimers without significant structural distortion, improving their stability, morphology, antigenicity, and immunogenicity for vaccine development.