Michael H. Malim

This study identifies POM121 as a regulator of lentiviral nuclear import, showing its effect is virus-specific and depends on capsid-host interactions.

This study shows that Gag proteolysis drives HIV-1 Env conformational closure through the gp41 cytoplasmic tail, revealing a mechanism for immune evasion.

This study identifies the minimal MX2 region required for HIV-1 restriction and shows that MX2 binding disrupts the capsid lattice, leading to premature fragmentation and preventing viral nuclear import.

The paper identifies diverse spike haplotypes in persistent SARS-CoV-2 infections that show immune escape mechanisms similar to variants of concern.

This paper shows that oncolytic Reovirus can eliminate SARS-CoV-2 in lung cells without causing toxicity by enhancing innate antiviral responses.

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.

This study shows CL-11 promotes SARS-CoV-2 invasion and injury of respiratory epithelial cells, suggesting CL-11 blockade could limit viral pathogenicity.

The paper examines the association between adipose tissue ACE2 expression and cardio-metabolic risk factors, finding lower ACE2 levels linked to T2D, obesity, and inflammation-related cell type changes.