Discover, rate, and discuss biology preprints.

This paper develops an inverse engineering framework to optimize crop phenotypes by integrating sensitivity analysis, genetic algorithms, and similarity analysis to identify adaptive strategies and breeding candidates.

This study shows that vertical ground reaction force morphology during walking reflects the imbalance between push-off and collision impulses, with a preferred balance at 1.2 m/s.

The paper introduces a biomechanics hand dataset containing kinematics, kinetics, electromyography, and imaging data from healthy adults to support musculoskeletal modeling.

This paper designs and verifies a multichannel tTIS system using individual MRI to precisely stimulate the deep brain with minimal misstimulation.

The paper develops a modified inverted pendulum model to show that human walking speed and step length are constrained by mechanical feasibility and work capacity, not just energy efficiency.

This study shows static mechanical stretch causes collective alignment of C2C12 myoblasts, with dense cultures aligning more robustly than sparse ones due to cellular forces and intercellular interactions.

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

This study introduces a nanopore-based method for glycan sequencing that reconstructs full glycan structures from fragments, overcoming limitations of existing approaches.

This paper introduces a modular system for real-time assessment of barrier integrity using impedance sensing in microphysiological systems.

The paper develops a synthetic immunological niche to identify early immune dysregulation and stratify therapeutic response in Type 1 Diabetes.

This study shows that combining physical and pharmacological anabolic therapies improves bone strength and mechanoregulation in female mice with osteoporosis.

This paper introduces an AI framework to improve mRNA therapeutic manufacturing by predicting and optimizing sequence design for in vitro transcription efficiency.

This study combines volumetric bioprinting with mineralization to create high-density cell-laden hydrogel constructs with bone-like properties.

This study uses Magnetic Ion Channel Activation to boost EV production from pre-osteoblasts, enhancing their osteogenic potential for bone regeneration.

FLEXTAG improves super-resolution imaging by enabling long-term, multi-color, low-bleaching labeling of subcellular structures in live and fixed cells.

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

This study shows that drug-free polymeric nanoparticles improve locomotor recovery after spinal cord injury in both sexes through sex-specific immune mechanisms.

This study enhances AOX1 promoter self-induction in K. phaffii by engineering serine metabolism to increase formate production, improving recombinant protein productivity without methanol.

This paper introduces a wireless photoacoustic neuromodulation patch that achieves stable, programmable acoustic focusing through geometric design, enabling precise deep-brain stimulation without electronic phase control.

The paper uses simulations to show brain microvascular networks provide oxygen supply resilience against hypoxia by maintaining oxygen tension through convective transport and capillary flow patterns.