Discover, rate, and discuss biology preprints.

This study engineers a co-culture of A. baylyi and E. coli to convert p-coumaric acid to cis,cis-muconic acid, achieving 18.55 mM ccMA with improved titres but highlighting metabolic pathway bottlenecks.

The paper compares transcriptomes of HDACs, TFs, and ion channels in hiPSC-CMs and adult human heart to identify regulatory relationships and cardiotoxicity implications of HDAC inhibitors.

This paper introduces nanotrap therapeutic vaccines (NTVs) that capture HIV virions and induce CD8 T cell immunity in mouse models.

This paper demonstrates DNA nanocages (TDNs) for targeted delivery of biomolecules into Arabidopsis pollen tubes, modulating growth through actin reorganization and ROS modulation.

PAVR enables high-resolution volumetric imaging of cells using a physics-aware framework trained on simulated data, demonstrating applications in tracking subcellular structures and analyzing cardiac cell dynamics.

This paper combines evolutionary algorithms with AI to design potent Nectin-4-specific cancer biologics, achieving high-affinity minibinders and functional reagents.

This paper creates a true Olympic gel from over 16,000 DNA rings, showing unique mechanical properties and swelling behavior due to entanglements.

This paper introduces a scanless, high-speed 3D quantitative phase microscopy technique with improved resolution and reduced noise, enabling label-free volumetric imaging of biological samples.

TurboPRANCE enables large-scale, multi-objective continuous evolution by integrating robotic systems with phage-assisted evolution, generating high-resolution evolutionary data across diverse selection regimes.

The paper develops a chemically defined, xeno-free hydrogel system that supports hPSC differentiation into multiple tissue types and improves hepatocyte retention in vivo.

This paper develops modular DNA scaffold crystals for programmable installation and structural observation of DNA-binding proteins, enabling high-throughput structure determination and functional applications.

This paper introduces spligation, a method using CRISPR-Csm complexes to generate chimeric RNA in living cells by enabling site-specific RNA cleavage and trans-ligation.

This study measures annular forces from TEER in porcine hearts, finding that force magnitude varies with clip placement and number of clips.

This paper develops a breath analysis method using a beta-lactamase-responsive probe to detect tuberculosis rapidly and non-invasively.

This study evaluates bioabsorbable magnesium wires in a murine wound model, showing improved granulation tissue, reduced inflammation, and enhanced neovascularization.

This study identifies a cardiac pulse signal affecting LFP recordings from DBS electrodes across multiple brain regions and patient groups, introducing an algorithm to detect and extract it.

This paper introduces an optical clearing method using tartrazine to enable non-invasive OCTA imaging of the mouse cortex through intact skull and scalp.

This study identifies a bacterial pathway for p-cresol removal and demonstrates its potential for gut-based detoxification.

This paper introduces an automated in-incubator microscope for long-term live cell imaging, enabling high-frequency, continuous data collection with improved thermal stability and operational reliability.