Discover, rate, and discuss biology preprints.

This study designs antibody Fc-variants with programmable functional profiles using deep learning and experimental validation.

This paper introduces a microfluidic chip protocol to create agarose-based microvascular phantoms for evaluating ultrasound localization microscopy (ULM) performance.

The paper tracks virus infection spread in HeLa cells using single-cell imaging and identifies differences in gene expression between primary and secondary infected cells.

DeviceAgent is an AI agent that integrates LLMs and VLMs to automate bioelectronics research tasks, demonstrating capabilities in design, fabrication, defect inspection, and electrophysiological analysis.

This paper engineers Acinetobacter baylyi ADP1 to efficiently utilize pentose sugars and produce L-glutamate, achieving high growth rates and carbon yields.

This study shows that multi-cellular human liver organoids can mature induced pluripotent hepatocyte-like cells through endogenous signals, achieving hepatic marker expression and function similar to primary human hepatocytes.

Fluid-Squid enables customizable, cost-effective multiplexed imaging of cells and tissues through automated fluidics and barcoding strategies.

This paper presents an implantable material platform that contains engineered bacteria to autonomously deliver therapeutics in a mouse model of prosthetic joint infection.

This paper develops a multi-task deep learning method to segment and parcellate fetal brain structures from diffusion MRI, achieving high accuracy in tissue segmentation, tract segmentation, and parcellation.

This study validates benchtop and finite element models of penile tissue inflation using human tissue tests to improve inflatable penile prosthesis design and surgical outcomes.

This study introduces CausaLink, a cross-scale causal mapping framework that identifies Mgl2 macrophages as key regulators of balanced arterial development using single-cell transcriptomics and organoid validation.

This paper describes engineered liver tissue that reverses acute liver failure in mice without immunosuppression, demonstrating potential for clinical translation.

This paper develops PEDOT:PSS granular hydrogel microparticles that form conducting hydrogels with microporosity and dynamic mechanical properties, enabling extrusion, bioencapsulation, and electrophysiological monitoring.

The paper develops a nanobody-gold conjugate for dual light-electron microscopy to label GFP-tagged synaptic proteins with high specificity and nanoscale resolution.

The paper introduces a microfluidic NMR platform to monitor metabolic fluxes in live tissue slices with high temporal resolution and broad metabolite coverage.

This study develops antimicrobial nanolayers of thymol and carvacrol on titanium surfaces, finding that thymol exhibits superior osteogenic effects compared to carvacrol due to differences in physicochemical properties.

PiP-plex enables multiplexed quantification of single-cell protein secretion using a particles-in-particle system, detecting cytokine responses in THP-1 cells to lipopolysaccharide.

This paper introduces a bioadhesive epicardium platform that modulates cardiac biomechanics after myocardial infarction in rats.

This study generates gene-modified cattle and sheep using haploid stem cells with a modified iCHI approach that enhances embryo development.

This paper develops a multi-modality MRI segmentation model to improve robustness of medial temporal lobe subregion segmentation in poor-quality images.