Discover, rate, and discuss biology preprints.

Constitutive artificial neural networks trained on biaxial tests of 8 ovine main pulmonary artery samples consistently discover a two-term model: exponential first-invariant plus quadratic fifth-invariant terms.

This paper develops a hyper-porous hydrogel encapsulation method for microbial cells, demonstrating improved biocatalytic efficiency in co-culture fermentation.

This paper develops a collagen bioink for delivering corneal stem cells to wounds, promoting transparency and re-epithelialization in a rabbit model.

This study introduces a criterion to detect inertial effects in capillary flows and shows how the Bosanquet equation can account for them in open-channel configurations.

This paper demonstrates engineered bacterial spores displaying enzymes for sustainable aliphatic polyester degradation, showing repeated reuse and full activity recovery.

This study demonstrates that immunomodulatory porous scaffolds improve vascular graft healing by promoting endothelialization and transmural cellular infiltration compared to standard PTFE grafts.

The paper investigates how inflammatory cytokines from macrophages differentially affect male and female valvular interstitial cells on hydrogel biomaterials, revealing sex-specific mechanisms in myofibroblast activation and osteoblast-like differentiation.

This study evaluates platelet-derived extracellular vesicles (PEVs) loaded with kaempferol for treating corneal neovascularization, showing reduced vessel formation and inflammation in a mouse model.

This study demonstrates how a circularly permuted enzyme can assemble into various hollow structures using pentamers, guided by structural and geometrical principles.

The paper introduces genetically encoded LLPS-sensors for probing biomolecular condensates in mouse skin, demonstrating their tunability and effectiveness in assessing intracellular phase separation dynamics.

This paper introduces an adaptive smoothing algorithm to separate transient and oscillatory components in neural signals, showing improved performance on synthetic and recorded data.

This paper introduces a novel gene synthesis method, SCRCA, for efficiently creating repetitive-sequence genes encoding functional protein polymers, showing higher efficiency and lower cost than conventional methods.

This paper develops SIRPα-expressing extracellular vesicles from engineered stem cells to treat acute liver failure by resolving necroptosis and promoting liver regeneration, showing reduced liver damage and improved survival in models.

This study compares reactor configurations for lactate production from acid whey, finding that a CSTR with a hollow-fiber membrane module achieved the highest conversion efficiency and rate.

The paper introduces AggreBots, a platform for creating designer motility patterns in multicellular tissues by spatially controlling the aggregation of epithelial spheroids, achieving greater motility than traditional CiliaBots.

This study uses molecular dynamics to investigate how lipid composition and protein concentration affect axonal membrane rupture, finding that node-of-Ranvier membranes rupture at lower strains than myelin.

This study introduces a 4D printed hydrogel scaffold that uses cell contractile forces to drive tissue morphogenesis, enabling programmed shape transformations and scaffold-free tissue constructs.

This paper develops a tunable hydrogel system using decellularized meniscus extracellular matrix to repair zonal-specific meniscal injuries, showing improved cell differentiation and tissue integration.

Luminos is an open-source MATLAB library for bidirectional microscopy that enables precise synchronization of stimulation, imaging, and experimental parameters.

This study improves spatial transcriptomics by visualizing cell boundaries without staining, leading to higher UMI counts and gene detection per cell.