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This study shows that high-viscosity hydrogels lead to increased nascent extracellular matrix deposition by cells, independent of intracellular contractility.

This paper develops an ultra-stable insulin-glucagon fusion protein that exploits a hepatic glucose switch to reduce hypoglycemic risk in diabetes, showing improved stability and glycemic control in rats.

The paper develops a large yeast surface display library to identify high-affinity peptide ligands for various protein targets, revealing binding motifs and novel clones.

The paper develops an ex vivo chick embryonic bone model using PLGA microparticles to study growth factor delivery effects on cell differentiation and tissue formation, showing that controlled release of BMP2 and FGF2 alters collagen deposition and cell morphology.

This paper develops a super-resolution reconstruction framework to improve the quantification of complete spatiotemporal myocardial strains in mice using cardiac MRI.

This paper develops an antibody-free lipid nanoparticle system for in vivo mRNA delivery to human HSCs, enabling efficient base editing of HBG to treat blood disorders like beta-thalassemia and sickle cell disease.

This study develops a high-throughput morphological assay to evaluate how MSC-EVs modulate brain pericyte secretory phenotype, showing distinct morphological responses under different manufacturing conditions.

This study investigates how temporal parameters of vagus nerve stimulation (VNS) affect neural plasticity, finding that moderate pulse frequencies enhance plasticity while burst patterns do not.

This paper presents a T cell gene correction pipeline using CRISPR/Cas9 and HDR to correct monogenic mutations in IEI models, achieving up to 80% bi-allelic editing with no detectable off-target effects.

This paper develops a personalized shoulder modeling framework that improves kinematic accuracy for multiple motions using closed-chain models with 5 DOFs.

This paper develops a bimodal imaging probe for monitoring systemic inflammation using immuno-PET and immuno-MRI, demonstrating its efficacy in a murine model of rhabdomyolysis.

This study introduces a microfluidic platform called -Blood to monitor Babesia microti infection dynamics in whole blood without preprocessing, enabling extended observation of parasite-host interactions.

This paper introduces an oxygen-generating encapsulation system for insulin-secreting cells that supports high-density packing and reverses diabetes in rats without immunosuppression.

This paper compares the performance of three microbes in dissolving ultramafic rock dunite, finding that Gluconobacter oxydans outperforms the others in acid production and metal extraction.

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

The paper uses simulation to show that multi-site tendon transfers can produce better-directed thumb-tip forces than single-site transfers for lateral pinch grasp in tetraplegia.

The paper presents a pipeline for 3D bioprinting microalgal constructs and simulating their photosynthetic performance using functional imaging and non-invasive techniques.

The paper investigates microdefects in hip-fracture patients and finds they are more prevalent and negatively correlate with bone strength.

This paper introduces PADAM, a time-domain passive cavitation imaging method that improves resolution and reduces artifacts compared to existing methods, enabling better cavitation monitoring and control in FUS therapy.

This paper demonstrates a DNA origami structure with dynamic size-switchability using i-motif and hairpin motifs, enabling contraction and expansion between 68 nm and 150 nm.