Discover, rate, and discuss biology preprints.

This paper introduces injectable hydrogels encapsulating SWCNT sensors for in situ drug concentration monitoring, showing preserved fluorescence response in physiological conditions.

This paper develops a mechanically adaptive artificial skin using entanglement-mediated protein networks, showing improved toughness, regenerative compatibility, and wound healing in mice.

This paper develops a predictive simulation framework using bi-level inverse optimal control to link preoperative implant alignment to postoperative squat kinematics after total knee replacement.

This study uses quantum dot imaging temperature sensors to measure brain temperature in mice, revealing vascular cooling's role in protecting against heat stress in pathological conditions.

This study validates dynamic Bayesian optimization (DBO) for human-in-the-loop exoskeleton control, showing it improves walking speed and personalization compared to standard Bayesian optimization (BO).

This study shows that optogenetic stimulation of cholinergic vagal neurons reduces pro-inflammatory cytokines, while glutamatergic stimulation does not, demonstrating the importance of pathway selectivity in vagus nerve stimulation.

This paper introduces a continuous twin-column capture process (CaptureSMB) for purifying rAAV5 directly from perfusion harvest, improving yield and efficiency while maintaining product quality.

This paper introduces a microfluidic method to generate scalable apical-out intestinal spheroids by encapsulating cells in core-shell hydrogel microcapsules.

This study evaluates signal peptide-driven protein secretion in Synechococcus sp. PCC 11901, finding that FutA from the Tat pathway outperforms Sec pathways, but optimal selection depends on the target protein.

This paper introduces a structural co-modulation measure to quantify individualized interactions between brain components using source-based morphometry, finding reduced co-modulation in schizophrenia patients.

This study uses AI to discover small molecules that rejuvenate hair follicles by targeting complementary pathways, showing increased cell viability and suppression of follicular miniaturization.

This study develops a microphysiological model of the human oral cavity to study host-microbe interactions during bacterial, fungal, and viral infections.

This study evaluates 3D-printed composite scaffolds for local chemotherapy delivery in spinal metastases, showing effective drug release and bone integration in animal models.

CORe Designer is a CRISPR tool that allows protein-centric design of guide RNAs and repair templates for proteome engineering, streamlining targeted mutagenesis experiments.

This study uses multiscale modeling to show that left atrial wall thickness significantly affects myocardial stresses and oscillatory shear, more than other factors like cavity volume or displacement.

The paper demonstrates a wireless RF resonator probe with a dual-drive pTx system to enhance MRI SNR in a localized region while minimizing transmit-field interactions.

This paper optimizes the growth of kombucha-derived cellulose non-wovens, evaluates their mechanical properties after different post-processing methods, and demonstrates their recyclability through enzymatic degradation and electrospinning.

This study shows pulsed electrical stimulation increases intestinal permeability by affecting tight junction proteins, potentially enabling better drug absorption.

SPOTTER enables automated, high-plex spatial proteomics and phosphoproteomics by barcoding proteins on tissue sections, achieving deep coverage with LC-MS/MS.

This study isolates and characterizes HMEC-1 extracellular vesicles, showing they enhance wound closure and have dual inflammatory effects on endothelial cells.