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Preserving Nanotherapy-Induced Allogeneic Murine Islet Graft Tolerance During Distal Methicillin-Resistant Staphylococcus aureus Skin Infection

This study shows that a nanotherapy (rPS) that induces islet graft tolerance can be compromised by MRSA infection, but combining it with methylprednisolone improves survival.

From Fill to Freeze: Redesigning homeRNA to Enable Robust Sampling and Scalable Downstream Processing Workflows for Remote Blood Transcriptomics

This paper validates the redesigned homeRNA platform's robustness to remote study stresses, showing it maintains RNA quality under varied conditions and storage times.

Material context and TGF-β blockade timing determine retained matrix in patient-derived bioprinted keratoconus stroma

This study shows that timing of TGF-β blockade and material context affect matrix retention in bioprinted keratoconus stroma, with optimal regimens improving collagen retention and reducing contractile gene expression.

Commensal Engineered Living Materials for Sustained Secretome Delivery and Wound Healing

This paper develops a commensal Engineered Living Material (cELM) that encapsulates bacteria to deliver a pro-healing secretome for chronic wound healing.

Extensional Flow Microfluidics Reveal Size-Dependent Core-Shell Mechanical Heterogeneity in Pancreatic Tumor Spheroids

This study uses microfluidics to show that pancreatic tumor spheroids of different sizes exhibit distinct mechanical behaviors, with larger spheroids showing core-shell heterogeneity.

MitoDecode: quantitative phenotypic decoding of mitochondrial stress states from fluorescence images

MitoDecode assesses mitochondrial stress types and severity from fluorescence images without segmentation, showing adaptability across cell types and stress conditions.

Unlocking Targeted Underwater Delivery of Coral Probiotics

This study develops alginate-based delivery systems for coral probiotics, showing increased probiotic colonization in treated corals.

RNA-triggered Cas12a2 antibacterial activity and resistance plasmid degradation

This study demonstrates that an inducible CRISPR/Cas12a2 system can reduce bacterial growth and plasmid DNA in vitro and in vivo by targeting resistance transcripts.

1D model simulations suggest biofilms can suppress cathodic H2 bubble formation

The paper uses computational modeling to show cathodic biofilms can reduce H2 loss and suppress bubble formation in microbial electrosynthesis systems.

Rapid Electro-optic Two-photon Bessel Light Sheet Fluorescence Lifetime Imaging for Tissue Volume Interrogation

This paper introduces a new two-photon fluorescence lifetime imaging technique for rapid volumetric imaging of biological samples with high resolution and low phototoxicity.

Live Droplet Single-Cell RNA Sequencing

The paper introduces Live D-seq, a method for longitudinal, non-destructive single-cell RNA sequencing, and demonstrates its ability to track cellular dynamics over time.

Transferrin receptor binding valency determines the circulating half-life and weight-loss efficacy of Fc-FGF21 in TfR-humanized mice

This study shows that Fc-FGF21's weight-loss efficacy depends on its circulating half-life, which is influenced by hTfR binding valency and BBB transport.

Bicarbonate-free pH neutralization resensitizes ovarian cancer to chemotherapy and is tracked by 3T CEST MRI

This study shows that inhibiting MCT1 and MCT4 with acriflavine neutralizes tumor acidosis, restores chemotherapy efficacy, and is monitored by 3T CEST MRI without using bicarbonate.

Cascaded Dual-Targeting (WTW/TAT) Liposomes Delivery DOX for Precision Glioblastoma Treatment

This paper develops a dual-targeting liposomal nanoplatform for glioblastoma treatment, showing improved drug delivery across the BBB and enhanced tumor suppression.

Large-scale AI-guided discovery of antifreeze peptides reveals functional tandem-repeat architectures

This study uses AI to discover antifreeze peptides, finding that tandem-repeat sequences are functional and effective in inhibiting ice recrystallization.

Metabolic engineering of Saccharomyces cerevisiae for improved polyphosphate production

This study engineers Saccharomyces cerevisiae to produce polyphosphate more efficiently by modifying metabolic pathways and growth conditions.

Biological Signaling Pathways Associated with Late Tendon Development in Chicken Embryos and Their Dependence on Mechanical Stimulation

This study identifies mechanotransduction pathways involved in chicken tendon development and shows how paralysis disrupts these processes.

N-GLYcanyzer monitoring of a microperfusion process reveals critical parameters' impact on Trastuzumab biosimilar N-glycoform time evolution

The paper uses N-GLYcanyzer to monitor Trastuzumab biosimilar N-glycoform changes in a microperfusion process, identifying key parameters affecting glycoform evolution.

Differential sensing with imprinted and non-imprinted organic electrochemical transistors reduces calibration drift in wearable sweat cortisol sensors

Material-driven fibronectin assembly enables low-dose BMP-2 to regenerate structurally mature bone in critical-sized load-bearing defects

This study shows that PEA-coated monetites functionalized with fibronectin and low-dose rhBMP-2 promote structurally mature bone regeneration in critical-sized defects.