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The paper investigates the mechanical properties of DNA double-crossover motifs using molecular dynamics simulations and finds anisotropic bending rigidity and twist stiffness.

This study benchmarks eleven force fields on twelve peptides to assess their ability to model folding behaviors, revealing structural biases and limitations in capturing disorder and secondary structure.

This study uses AI and molecular modeling to analyze the structure and substrate-binding of two xanthan gum glycosyltransferases, revealing differences in their catalytic mechanisms and membrane interactions.

The paper shows that cortical flow reinforces PAR polarity against CDC-42 perturbations in C. elegans embryos, with different robustness across developmental contexts.

This study introduces FD-MD simulations to show that condensate interfaces enhance amyloid nucleation through β-motifs and molecular flux, leading to different growth morphologies and aging trajectories.

This study compares the individuality and information content of infrared molecular profiles with clinical laboratory data in a longitudinal cohort, finding infrared profiles more informative for individual identification.

This study identifies three migration modes—gripping, slipping, and stick-slip—determined by substrate properties and actin polymerization speed, showing stiffness sensing occurs only in stick-slip mode.

The paper uses cryo-electron microscopy and proteomics to reveal the structural features of the E. coli Stx bacteriophage phi24B, including its icosahedral capsid and tail assembly.

This paper introduces iNTA-F, a method combining interferometric nanoparticle tracking analysis with fluorescence detection to characterize nanoparticles with single-molecule sensitivity.

This study uses live cell FRET microscopy to show that adenovirus E1A's structural ensemble and nuclear/cytoplasmic partitioning change during infection.

The paper uses FragLites to map BRD4 recruitment sites on cyclin T2, revealing interactions with CDK9, AFF4, and HIV-1 Tat, and integrates this with biophysical and AlphaFold3 analyses to define the cyclin T-BRD4 interface.

This paper introduces FluoroCubes as fiducial markers for traction force microscopy, enabling high-resolution force mapping with improved sensitivity and compatibility with TIRF microscopy.

This study investigates TMPyP4's selective binding to HRAS2 i-Motif DNA using multimodal biophysical and thermodynamic methods, revealing its stabilization and fluorescent response properties.

This study uses cryo-EM and myosin motors to show that wild-type α-actinin-4 forms two binding states with F-actin, while the K255E variant only forms strong bonds, revealing a force-induced transition mechanism for catch bonding.

RNASCAPE quantifies mRNA cytosolic escape using deep learning, achieving 78% accuracy with three timepoints and LNP parameters, revealing cholesterol's impact on mRNA release.

This study uses cryo-EM to reveal structural polymorphism in ex-vivo ALECT2 amyloid fibrils, identifying three morphologies and acetylation sites.

This study investigates how N-terminal acetylation affects biomolecular condensation using Grh1 in yeast, showing it alters condensate properties like size, stability, and structure.

This study uses cryo-ET to examine how two IgGs bind to SARS-CoV-2 S-trimers, revealing structural mechanisms of bivalent binding and antibody avidity.

This study investigates how H2A.Z affects Sox2 and Oct4 binding to nucleosomes by altering DNA and histone H3 tail dynamics.

This study uses NMR spectroscopy to reveal how the trivalent binding sites of CpCBM92A interact with beta-glucan ligands, showing distinct roles and affinities for cross-linking.