Shahar Sukenik

This study identifies a geothermal amoeba that divides at 63°C, setting a new upper temperature limit for eukaryotes and challenging existing paradigms about eukaryotic thermal tolerance.

This study investigates how alternative splicing of intrinsically disordered regions in the fungal circadian protein FRQ affects temperature-dependent clock function.

This paper introduces GOOSE, a computational framework for designing intrinsically disordered proteins, and demonstrates its ability to create IDRs with specific functional responses.

The paper investigates how intramolecular interactions between folded and disordered regions of ubiquilin proteins influence their structure and function across different species.

This study uses live cell FRET microscopy to show that adenovirus E1A's structural ensemble and nuclear/cytoplasmic partitioning change during infection.

This study examines how four Arabidopsis LEA proteins respond structurally and functionally to environmental changes, revealing distinct protective mechanisms under desiccation.

This study identifies the STI1 domain's role in driving Dsk2 self-association and phase separation through interactions with transient helices in disordered regions, with implications for proteasome condensate formation.

This study shows LEA_4 motifs protect an enzyme during desiccation, with enhanced protection when combined with synergistic cosolutes.

The paper investigates how structural ensembles of disordered activation domains correlate with transcriptional activity through mutational analysis of HIF-1 and CITED2.

The paper identifies protein surface chemistry as a determinant of desiccation tolerance and shows that modifying surface amino acids can confer tolerance to otherwise sensitive proteins.

This study investigates how disordered proteins interact with endogenous cosolutes during drying to enhance desiccation protection across different organisms.