Discover, rate, and discuss biology preprints.

The paper uses the RAG framework to identify new viral RNA motifs from PDB structures, expanding the RNA Motif Atlas to 197 dual graph motifs.

This study uses molecular dynamics simulations to show how CD8 modulates the mechanical stability and dissociation pathways of the TCR-pMHC complex.

This paper develops a stochastic kinetic model of splicing to predict mRNA isoform levels from site-specific splicing kinetics and validates it under normoxia and hypoxia.

The paper presents the cryo-EM structure of human NM2B in the autoinhibited 10S conformation, revealing structural mechanisms of autoinhibition and implications for disease.

This paper uses molecular dynamics simulations to show how different antimicrobial peptides alter membrane mechanical properties in a dose-dependent manner, with structured peptides causing greater softening than disordered ones.

This study demonstrates that microtubule bundling can occur through condensate-mediated capillary forces, independent of bulk protein concentration.

The paper uses molecular dynamics simulations to show that phosphate release from actin filaments is limited by dissociation from Mg2+ and varies with subunit position and water molecule count.

The paper develops an electrodiffusion active pump model using immersed boundary methods to simulate ionic transport and volume homeostasis, showing good fit to theoretical predictions and satisfying electroneutrality.

AFM-Fold reconstructs 3D protein conformations from AFM images using a generative AI framework, outperforming rigid-body fitting and capturing conformational dynamics.

This study identifies a volatile anaesthetic binding site in voltage-gated sodium channels, showing it modulates channel function and reduces neuronal excitability.

The paper derives scaling equations for contact parameters in musculoskeletal simulations to account for body size, limb count, and contact spheres, demonstrating geometrically and dynamically similar behavior across species.

This paper analyzes 160 bispecific antibodies and their parental arms to identify developability inheritance patterns and predictive models for bispecific antibody design.

This study uses single-molecule assays to show eIF4F binding and mRNA remodeling during translation initiation, revealing ATP-dependent conformational changes and their role in ribosome loading.

This paper identifies minimal monomer design principles for treadmilling filaments using physical modeling and in silico evolution, showing how conformational changes enable directional growth and fragmentation-free disassembly.

This study shows that Scn1b haploinsufficiency causes structural changes in cardiac intercalated discs that increase sensitivity to osmotic stress, unmasking concealed conduction abnormalities.

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

The paper introduces a 3D viscoelastic cell-network model that links single-cell interactions to tissue rheology, validated against experimental assays.

This study shows that wrinkles in biofilms arise from matrix complementarity and mechanical discontinuity between bacterial strains.

This study investigates how the allosteric inhibitor G6PDi-1 affects G6PD activity by combining biochemical assays and computational methods, revealing binding sites and allosteric effects that disrupt oligomerization.